Impaired executive functions in experimental model of temporal lobe epilepsy

Author(s)

Ramos, Fabiane Ochai ^{[1, 2]} ; Rodrigues Carreiro, Luiz Renato ^[1] ; Scorza, Fulvio Alexandre ^[2] ; Cysneiros, Roberta Monterazzo ^[1]

Affiliation

^[1] Univ Presbiteriana Mackenzie, Lab Neurobiol, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurocirurgia, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Arquivos de Neuro-Psiquiatria; v. 74, n. 6, p. 470-477, JUN 2016.
• Web of Science Citations: 2

Abstract

Objective: The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method: Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results: Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. Conclusion: Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior. (AU)

• FAPESP's process: 11/50680-2 - Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools
• Grantee: Iscia Teresinha Lopes Cendes
• Support type: Research Projects - Thematic Grants