| Full text | |
| Author(s): |
Ramos, Fabiane Ochai
[1, 2]
;
Rodrigues Carreiro, Luiz Renato
[1]
;
Scorza, Fulvio Alexandre
[2]
;
Cysneiros, Roberta Monterazzo
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Presbiteriana Mackenzie, Lab Neurobiol, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurocirurgia, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Arquivos de Neuro-Psiquiatria; v. 74, n. 6, p. 470-477, JUN 2016. |
| Web of Science Citations: | 3 |
| Abstract | |
ABSTRACT Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. Conclusion Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior. (AU) | |
| FAPESP's process: | 11/50680-2 - Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools |
| Grantee: | Iscia Teresinha Lopes Cendes |
| Support Opportunities: | Research Projects - Thematic Grants |