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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impaired executive functions in experimental model of temporal lobe epilepsy

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Author(s):
Ramos, Fabiane Ochai [1, 2] ; Rodrigues Carreiro, Luiz Renato [1] ; Scorza, Fulvio Alexandre [2] ; Cysneiros, Roberta Monterazzo [1]
Total Authors: 4
Affiliation:
[1] Univ Presbiteriana Mackenzie, Lab Neurobiol, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurocirurgia, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Arquivos de Neuro-Psiquiatria; v. 74, n. 6, p. 470-477, JUN 2016.
Web of Science Citations: 2
Abstract

Objective: The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method: Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results: Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. Conclusion: Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior. (AU)

FAPESP's process: 11/50680-2 - Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools
Grantee:Iscia Teresinha Lopes Cendes
Support type: Research Projects - Thematic Grants