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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Serum Levels of Cardiac Markers NT-proANP and NT-proBNP in Brachycephalic bitches at Different Gestational Stages

Full text
Author(s):
Feliciano, M. A. R. [1] ; Uscategui, R. R. [1] ; Maciel, G. S. [1] ; de Almeida, V. T. [1] ; Silveira, M. F. [1] ; de Oliveira, G. A. C. [1] ; Vicente, W. R. R. [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista UNESP, Sch Agr & Vet Sci, Dept Anim Reprod, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: REPRODUCTION IN DOMESTIC ANIMALS; v. 51, n. 3, p. 346-350, JUN 2016.
Web of Science Citations: 0
Abstract

The aim of this study was to determine serum levels of natriuretic peptide precursors (NT-proANP and NT-proBNP) during pregnancy in brachycephalic bitches. Fifteen healthy multiparous bitches were selected for this prospective study. Serum levels of NT-proANP and NT-proBNP were measured during anoestrous and at 14, 35, 42, 49 and 56 days (2nd, 5th, 6th, 7th and 8th weeks) of pregnancy. Fourteen animals had normal gestations, and one bitch developed single foetus syndrome. The natriuretic peptide levels of this animal were not included in this study; however, it is important to report that its NT-proANP levels were four times greater than those of normal patients. There was no significant difference (p = 0.072) in NT-proBNP levels between anoestrous (0.20 +/- 0.10 ng/ml) and the different pregnancy weeks (0.27 +/- 0.12 ng/ml). There was a positive correlation (p < 0.0001) between NT-proANP and gestational age, and the levels of this marker increased significantly (p < 0.0001) during the 6th (0.26 +/- 0.06 ng/ml), 7th (0.28 +/- 0.04 ng/ml) and 8th weeks (0.29 +/- 0.05 ng/ml) when compared to anoestrous (0.18 +/- 0.02 ng/ml). NT-proANP serum levels are correlated with gestational development and may be indicative of cardiovascular adaptation in canine brachycephalic pregnancy. (AU)

FAPESP's process: 12/16635-2 - Elastography, contrast enhanced ultrasonography and Doppler as diagnostic of method of the mammary neoplasm, prostatic and testicular diseases in canines
Grantee:Marcus Antônio Rossi Feliciano
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 10/16913-7 - Conventional ultrassonography and Dopplerflow maternal fetal prenatal in evaluation of pregnant bitches
Grantee:Marcus Antônio Rossi Feliciano
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 11/06011-9 - Conventional ultrasound and Doppler in maternal-fetal prenatal evaluation of pregnant bitches
Grantee:Wilter Ricardo Russiano Vicente
Support Opportunities: Regular Research Grants