Bacterial Cellulose Membranes as a Potential Drug Delivery System for Photodynamic Therapy of Skin Cancer

Author(s)

Maristela F. S. Peres ^[1] ; Karina Nigoghossian ^[2] ; Fernando L. Primo ; Sybele Saska ^[4] ; Ticiana S. O. Capote ^[5] ; Raquel M. S. Caminaga ^[6] ; Younes Messaddeq ^[7] ; Sidney J. L. Ribeiro ^[8] ; Antonio C. Tedesco ^[9]

Affiliation

^[1] Universidade de São Paulo. Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Departamento de Química - Brasil

^[2] Universidade Estadual Paulista "Júlio de Mesquita Filho". Instituto de Química - Brasil

^[4] Universidade Estadual Paulista "Júlio de Mesquita Filho". Instituto de Química - Brasil

^[5] Universidade Estadual Paulista "Júlio de Mesquita Filho". Faculdade de Odontologia. Departamento de Morfologia - Brasil

^[6] Universidade Estadual Paulista "Júlio de Mesquita Filho". Faculdade de Odontologia. Departamento de Morfologia - Brasil

^[7] Universidade Estadual Paulista "Júlio de Mesquita Filho". Instituto de Química - Brasil

^[8] Universidade Estadual Paulista "Júlio de Mesquita Filho". Instituto de Química - Brasil

^[9] Universidade de São Paulo. Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Departamento de Química - Brasil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 27, n. 11, p. 1949-1959, 2016-11-00.

Abstract

The development of drug delivery systems for photodynamic therapy (PDT) is increasingly demanded due to the hydrophobicity presented by most of photosensitizers molecules. Bacterial cellulose (BC), a highly pure cellulose produced by bacteria, possesses the essential features for applications in drug delivery systems, such as large surface area and excellent loading capacity. BC membranes prepared containing a photosensitizer, chloroaluminum phthalocyanine (ClAlPc), were tested aiming applications as a drug delivery system for PDT skin cancer protocols. BC membranes production was optimized regarding thickness and optical transmission. Thinner membranes lead to higher relative incorporation efficiencies. Skin permeation and retention in vitro tests were performed by using pig's ears as a skin model. ClAlPc was retained at stratum corneum and epidermis/dermis, showing adequate properties for topical administration of ClAlPc. Photophysical studies showed that singlet oxygen production was not affected for ClAlPc compartmentalized in the BC array. BC-ClAlPc membranes did not present cytotoxic effects in vitro. (AU)

• FAPESP's process: 11/15759-7 - Cellulose membranes containing nanoparticles for upconversion of energy. Fundamentals and applications.
• Grantee: Karina Nigoghossian
• Support Opportunities: Scholarships in Brazil - Master