Confining a Biocatalyst for Highly Efficient and Selective Synthesis of Carboxamide Derivatives under Continuous-Flow Conditions

Andrade, Leandro H.; Sousa, Bruno A.; Jamison, Timothy F.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Confining a Biocatalyst for Highly Efficient and Selective Synthesis of Carboxamide Derivatives under Continuous-Flow Conditions

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Author(s):	Andrade, Leandro H. ; Sousa, Bruno A. ; Jamison, Timothy F. Total Authors: 3
Document type:	Journal article
Source:	JOURNAL OF FLOW CHEMISTRY; v. 6, n. 2, p. 67-72, JUN 2016.
Web of Science Citations:	3
Abstract
The confinement of a biocatalyst designed to operate under continuous-flow conditions is a strategy developed by nature in order to achieve efficient reactions in biological media. Herein, we present a mimetic model that employs a confined lipase (CAL-B) in the production of several carboxamide derivatives from esters as precursors. The remarkable selectivity of such system is also described when alpha,beta-unsatured carboxylic substrates are employed. (AU)

FAPESP's process:	14/22457-5 - Development of biocatalytic systems for oxidation and reduction reactions
Grantee:	Leandro Helgueira de Andrade
Support Opportunities:	Regular Research Grants


FAPESP's process:	13/04540-0 - Enzymatic transformation of CO2 under continuous flow
Grantee:	Leandro Helgueira de Andrade
Support Opportunities:	Scholarships abroad - Research

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