Achieving regio- and stereo-control in the fluorination of aziridines under acidic conditions

Okoromoba, Otome E.; Li, Zhou; Robertson, Nicole; Mashuta, Mark S.; Couto, Uenifer R.; Tormena, Claudio F.; Xu, Bo; Hammond, Gerald B.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Achieving regio- and stereo-control in the fluorination of aziridines under acidic conditions

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Author(s):	Okoromoba, Otome E. ; Li, Zhou ; Robertson, Nicole ; Mashuta, Mark S. ; Couto, Uenifer R. ; Tormena, Claudio F. ; Xu, Bo ; Hammond, Gerald B. Total Authors: 8
Document type:	Journal article
Source:	CHEMICAL COMMUNICATIONS; v. 52, n. 91, p. 13353-13356, 2016.
Web of Science Citations:	23
Abstract
We developed an efficient fluorination protocol that converts easily accessible aziridines into beta-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU-HF has shown both higher reactivity and regioselectivity and good functional group tolerance; thus, a wide scope of beta-fluoroamines can now be accessed conveniently. The stereochemical behavior of the ring opening depends on the substitution pattern of the aziridine substrate. (AU)

FAPESP's process:	15/08541-6 - Nuclear magnetic resonance spectroscopy: beyond molecular structure assignment
Grantee:	Claudio Francisco Tormena
Support Opportunities:	Research Projects - Thematic Grants

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