Effects of late exercise on cardiac remodeling and myocardial calcium handling proteins in rats with moderate and large size myocardial infarction

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Guizoni, Daniele M. ; Oliveira-Junior, Silvio A. ; Noor, Sefora L. R. ; Pagan, Luana U. ; Martinez, Paula F. ; Lima, Aline R. R. ; Gomes, Mariana J. ; Damatto, Ricardo L. ; Cezar, Marcelo D. M. ; Bonomo, Camila ; Zornoff, Leonardo A. M. ; Okoshi, Katashi ; Okoshi, Marina P.

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF CARDIOLOGY; v. 221, p. 406-412, OCT 15 2016.
• Web of Science Citations: 12

Abstract

Background: Physical exercise attenuates myocardial infarction (MI)-induced cardiac remodeling. However, it is unsettled whether late exercise modulates post-infarction cardiac remodeling differentially according to infarct size. We investigated the effects of exercise started at late stage heart failure on cardiac remodeling in rats with moderate and large sized MI. Methods: Three months after MI, rats were assigned into sedentary and exercise groups. Exercise rats underwent treadmill for three months. After assessing infarct size by histological analysis, rats were subdivided into four groups: moderate MI sedentary (Mod MI-Sed; n = 7), Mod MI exercised (Mod MI-Ex; n = 7), Large MI-Sed (n=11), and Large MI-Ex (n=10). Results: Before exercise, MI-induced cardiac changes were demonstrated by comparing results to a Sham group; alterations were more intense in rats with large than moderate MI size. Systolic function, evaluated by echocardiogramusing the variation in LV fractional area change between after and before exercise, was improved in exercise than sedentary groups. Calsequestrin expression increased in exercised compared to sedentary groups. L-type calcium channel was higher in Mod MI-Ex than Mod MI-Sed. SERCA2a, phospholamban, and Na+/Ca2+ exchanger expression did not differ between groups. Conclusion: Late exercise improves systolic function andmodulates intracellular calciumsignaling proteins in rats with moderate and large MI. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU)

• FAPESP's process: 10/02077-2 - Effects of exercise training on soleus muscle myostatin and follistatin expression and trophism in rats with chronic heart failure.
• Grantee: Daniele Mendes Guizoni
• Support type: Scholarships in Brazil - Master
• FAPESP's process: 12/21687-1 - Influence of N-acetylcysteine on apoptosis signaling in skeletal muscle of rats with chronic heart failure
• Grantee: Marina Politi Okoshi
• Support type: Regular Research Grants