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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sperm quality and fertility in rats after prenatal exposure to low doses of TCDD: A three-generation study

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Author(s):
Sanabria, Marciana ; Cucielo, Maira Smaniotto ; Guerra, Marina Trevizan ; Borges, Cibele dos Santos ; Banzato, Thais Petrochelli ; Perobelli, Juliana Elaine ; Araujo Leite, Gabriel Adan ; Anselmo-Franci, Janete Aparecida ; Kempinas, Wilma De Grava
Total Authors: 9
Document type: Journal article
Source: REPRODUCTIVE TOXICOLOGY; v. 65, p. 29-38, OCT 2016.
Web of Science Citations: 8
Abstract

Exposure to Tetrachlorodibenzo-p-dioxin (TCDD) in male rats promotes, decreased sperm concentration, alterations in motility and in sperm transit time. We evaluated the effect transgenerational of in utero exposure to low doses TCDD in the sperm quality. Pregnant rats (F0) were exposed to 0.1; 0.5 and 1.0 mu g of TCDD, on gestational day 15, coincides with the end of most organogenesis in the fetus. Adult male offspring (F1, F2 and F3 generation) were investigated for fertility after artificial insemination in utero. After collection of the uterus and ovaries, the numbers of corpora lutea and implants were determined. TCDD provoked alterations in sperm morphology and diminution in serum testosterone levels and sperm transit time in the cauda epididymis. The fertility significantly decreased in all the generations, at least at one dose. In conclusion, TCDD exposure decreases rat sperm quality and fertility in adult male offspring and this effects persist into the next generation. (C) 2016 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/13312-8 - Reproductive toxicology of adult rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and during lactation
Grantee:Maira Smaniotto Cucielo
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/00365-6 - Reproductive toxicology of adult rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and during lactation
Grantee:Marciana Sanabria
Support type: Scholarships in Brazil - Doctorate