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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Do HLA class II genes protect against pulmonary tuberculosis? A systematic review and meta-analysis

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Author(s):
Oliveira-Cortez, A. ; Melo, A. C. ; Chaves, V. E. ; Condino-Neto, A. ; Camargos, P.
Total Authors: 5
Document type: Review article
Source: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES; v. 35, n. 10, p. 1567-1580, OCT 2016.
Web of Science Citations: 6
Abstract

Pulmonary tuberculosis (PTB) develops by a complex combination of environmental, immunological and socioeconomic factors and genetic susceptibility. The human leukocyte antigen (HLA) is the most polymorphic biological system and plays an essential role in the immune response against PTB. The aim of this study was to carry out a systematic review and meta-analysis evaluating the relationship between HLA-DRB1, HLA-DQB1 and HLA-DQA1 gene polymorphisms as possible risk or protective factors for PTB. A systematic search of the PubMed and Scopus databases was conducted following the guidelines described in the PRISMA statement. Fifty-six alleles were included in the meta-analysis. In the total pooled results, HLA-DRB1{*}08:03 (OR 1.95, CI 1.29-2.96), HLA-DQB1{*}06:01 (OR 1.78, CI 1.39-2.28), HLA-DQB1{*}06:09 (OR 2.27, 95 % CI 1.04-4.96) and HLA-DQA1{*}01:01 (OR 2.12, CI 1.11-4.03) genes were related to higher susceptibility to PTB. Conversely, the presence of the genes HLA-DRB1{*}07:01 (OR 0.74, CI 0.56-0.97), HLA-DQB1{*}03:01 (OR 0.77, CI 0.61-0.97), HLADQB1{*}04:02 (OR 0.57, CI 0.39-0.83), HLA-DQA1{*}04:01 (OR 0.50, CI 0.26-0.95) and HLA-DQA1{*}05:01 (OR 0.66, CI 0.48-0.92) demonstrated protection against PTB. In an analysis by ethnic subgroups, we found more genetic associations in Caucasians than in Asians. These findings suggest that HLAs may be used as markers for acquisition and development of PTB. To strengthen PTB susceptibility/resistance, we recommend further multicentric studies in different geographic regions, with certainty of controls' exposure to M. tuberculosis by use of marker of latent or active PTB, with analysis stratified by ethnic groups, with descriptions of specific alleles and carrying out immunological functionality tests. (AU)

FAPESP's process: 13/50303-0 - Human anti-tuberculous IFN-y-dependent immunity is mediated by the phagocytic NADPH oxidase
Grantee:Antonio Condino Neto
Support Opportunities: Regular Research Grants