Prenatal alcohol exposure reduces mandibular calcium and phosphorus concentrations in newborn rats

Author(s)

Carvalho, Isabel C. S. ; Martinelli, Carolina da S. M. ; Milhan, Noala V. M. ; Marchini, Adriana M. P. da S. ; Dutra, Tamires P. ; de Souza, Daniela M. ; da Rocha, Rosilene F.

• Document type: Journal article
• Source: JOURNAL OF ORAL SCIENCE; v. 58, n. 3, p. 439-444, SEP 2016.
• Web of Science Citations: 1

Abstract

Previous studies suggest that prenatal alcohol exposure affects fetal bone development, including bone quality. This study evaluated the chemical composition of mandibles from newborn rats after maternal 20% alcohol consumption before and throughout gestation. Nine rats were initially distributed into three groups: an Alcohol group, Pair fed group, and Control group. The groups were fed prespecified diets for 8 weeks before and the 3 weeks during pregnancy. At age 5 days, eight newborns from each group were euthanized (total, n = 24). Using energy dispersive spectrometry, we evaluated samples of mandibles from newborns to identify changes in bone mineralization, specifically Ca and P concentrations. Ca and P concentrations were lower in the Alcohol group than in the Control and Pair-fed groups (P = 0.003 and P = 0.001, respectively). In summary, alcohol exposure before and throughout gestation reduces mandibular Ca and P concentrations in newborn rats. (AU)

• FAPESP's process: 12/10643-3 - CYTOTOXIC AND GENOTOXIC EVALUATION OF NEWBORN' OSTEOBLASTS OF ALCOHOLICS RATS
• Grantee: Rosilene Fernandes da Rocha
• Support Opportunities: Regular Research Grants