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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between polymorphisms in xenobiotic detoxification-related genes with prognosis of epithelial ovarian cancer

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Author(s):
Carron, Juliana ; Carvalho Brito, Angelo Borsarelli ; Mourao Torelli, Ana Carolina ; Oliveira, Cristiane ; Mauricette Derchain, Sophie Francoise ; Passos Lima, Carmen Silvia ; Lourenco, Gustavo Jacob
Total Authors: 7
Document type: Journal article
Source: MEDICAL ONCOLOGY; v. 33, n. 10 OCT 2016.
Web of Science Citations: 1
Abstract

This study aimed to evaluate whether GSTM1 and GSTT1 (presents or nulls), GSTP1 c.313A>G and NQO2 c.-102A>C polymorphisms, involved in xenobiotic detoxification pathways, alter outcomes of epithelial ovarian cancer (EOC) patients. DNA from 84 EOC patients diagnosed at the University of Campinas Academic Hospital from January 1995 and July 2007 was analyzed by polymerase chain reaction and restriction fragment length polymorphism assays. The prognostic impact of genotypes of polymorphisms on progression-free survival and overall survival (OS) of EOC patients was examined using the Kaplan-Meier probability estimates and univariate and multivariate Cox proportional hazard ratio (HR) regression analyses. The significant results of Cox analyses were validated using a (bootstrap) resampling study (1000 replications). At 60 months of follow-up, lower OS was seen in patients with GSTT1 null genotype (50.0 vs. 76.7 %, P = 0.02) compared with the other genotype (Kaplan-Meier estimate). This outcome remained the same in univariate Cox analysis (HR 2.22, P = 0.02). After multivariate Cox analysis, patients with GSTT1 null (HR 2.11, P = 0.04, P-bootstrap = 0.04) and NQO2 AA (HR 2.13, P = 0.03, P-bootstrap = 0.04) genotypes were under greater risks of progressing to death when compared with those with others genotypes. Our data suggest, for the first time, that inherited abnormalities in xenobiotic detoxification pathway related to GSTT1 and NQO2 c.-102A>C polymorphisms act as independent prognostic factors for OS of EOC patients. (AU)