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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dorsal Anterior Cingulate Lactate and Glutathione Levels in Euthymic Bipolar I Disorder: H-1-MRS Study

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Author(s):
Soeiro-de-Souza, Marcio Gerhardt ; Pastorello, Bruno F. ; Leite, Claudia da Costa ; Henning, Anke ; Moreno, Ricardo A. ; Garcia Otaduy, Maria Concepcion
Total Authors: 6
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY; v. 19, n. 8 AUG 2016.
Web of Science Citations: 12
Abstract

Oxidative stress and mitochondrial dysfunction are 2 closely integrated processes implicated in the physiopathology of bipolar disorder. Advanced proton magnetic resonance spectroscopy techniques enable the measurement of levels of lactate, the main marker of mitochondrial dysfunction, and glutathione, the predominant brain antioxidant. The objective of this study was to measure brain lactate and glutathione levels in bipolar disorder and healthy controls. Eighty-eight individuals (50 bipolar disorder and 38 healthy controls) underwent 3T proton magnetic resonance spectroscopy in the dorsal anterior cingulate cortex (2x2x4.5cm(3)) using a 2-D JPRESS sequence. Lactate and glutathione were quantified using the ProFit software program. Bipolar disorder patients had higher dorsal anterior cingulate cortex lactate levels compared with controls. Glutathione levels did not differ between euthymic bipolar disorder and controls. There was a positive correlation between lactate and glutathione levels specific to bipolar disorder. No influence of medications on metabolites was observed. This is the most extensive magnetic resonance spectroscopy study of lactate and glutathione in bipolar disorder to date, and results indicated that euthymic bipolar disorder patients had higher levels of lactate, which might be an indication of altered mitochondrial function. Moreover, lactate levels correlated with glutathione levels, indicating a compensatory mechanism regardless of bipolar disorder diagnosis. (AU)

FAPESP's process: 10/18672-7 - SPECGENE: genetic association study between single nucleotide polymorphisms of GAD1 and reelin and magnetic ressonance spectroscopy in bipolar I
Grantee:Ricardo Alberto Moreno
Support Opportunities: Regular Research Grants
FAPESP's process: 12/23796-2 - "Genetic association study between cognitive performance, polymorphisms of GAD1/Reelin and 3T magnetic ressonance spectroscopy of GABA/glutamate in bipolar I disorder and healthy controls"
Grantee:Márcio Gerhardt Soeiro-de-Souza
Support Opportunities: Scholarships in Brazil - Post-Doctoral