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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The future of computational biomedicine: Complex systems thinking

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Author(s):
Joly, Marcel ; Rondo, Patricia H. C.
Total Authors: 2
Document type: Journal article
Source: MATHEMATICS AND COMPUTERS IN SIMULATION; v. 132, p. 1-27, FEB 2017.
Web of Science Citations: 4
Abstract

``More is different{''} (Philip W. Anderson). Complex systems thinking become instrumental for the modern understanding basis of life sciences in general and, hence, medicine and public health. In this perspective paper, we discuss recent literature and invite readers to explore the utility of complex thinking to properly addressing the constrained-based analysis of high-profile open questions in biomedicine with straightforward implications on public health. Recommendations are then proposed to encourage new multidisciplinary teams to come together in a timely manner in response to novel challenges in the theoretical physiology arena. We conclude that there is the need for far greater attention to the issue of complexity to aptly cope with a new array of problems that would have been unthinkable just a few years ago. (C) 2015 International Association for Mathematics and Computers in Simulation (IMACS). Published by Elsevier B.V. All rights reserved. (AU)