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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cholinergic agonist reverses H1-induced memory deficit in mice

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Author(s):
Fernandes, C. E. M. ; Serafim, K. R. ; Gianlorenco, A. C. L. ; Mattioli, R.
Total Authors: 4
Document type: Journal article
Source: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 72, p. 16-22, JAN 4 2017.
Web of Science Citations: 1
Abstract

This study investigated the effects of bilateral intraamygdalar microinjections of PNU-282987, a nicotinic cholinergic agonist, on anxiety and the reversal of amnesia induced by chlorpheniramine (CPA), an H1 histaminergic antagonist, in mice subjected to the elevated plusmaze (EPM). Two experiments were performed with seventy-nine adult male Swiss mice. The isolated microinjections of PNU-282987 did not produce effects on emotional memory; however, the combined microinjections of PNU-282987 and CPA were able to reverse the deficit in memory induced by CPA (ANOVA, p < 0.05). Taken together, these results suggest that intraamygdalar injections of PNU-282987 did not induce effects on anxiety and emotional memory per se; however, concurrent microinjections of PNU-282987 and CPA-reverse amnesia induced-CPA which is suggestive of an interaction between the histaminergic and cholinergic systems in the modulation of emotion memory acquisition in mice. (C) 2016 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/10913-0 - INTERACTION OF NEURAL HISTAMINERGIC AND CHOLINERGIC SYSTEMS IN THE AMYGDALA OF MICE: EMOTIONAL MEMORY MODULATION
Grantee:Kelly Regina Serafim
Support Opportunities: Scholarships in Brazil - Post-Doctoral