Metaboreflex activation delays heart rate recovery after aerobic exercise in never-treated hypertensive men

Author(s)

Pecanha, Tiago ; de Brito, Leandro Campos ; Fecchio, Rafael Yokoyama ; de Sousa, Patricia Nascimento ; da Silva Junior, Natan Daniel ; de Abreu, Andrea Pio ; da Silva, Giovanio Vieira ; Mion-Junior, Decio ; de Moraes Forjaz, Claudia Lucia

• Document type: Journal article
• Source: JOURNAL OF PHYSIOLOGY-LONDON; v. 594, n. 21, p. 6211-6223, NOV 2016.
• Web of Science Citations: 5

Abstract

Muscle metaboreflex influences heart rate (HR) regulation after aerobic exercise. Therefore, increased metaboreflex sensitivity may help to explain the delayed HR recovery (HRR) reported in hypertension. The present study assessed and compared the effect of metaboreflex activation after exercise on HRR, cardiac baroreflex sensitivity (cBRS) and heart rate variability (HRV) in normotensive (NT) and hypertensive (HT) men. Twenty-three never-treated HT and 25 NT men randomly underwent two-cycle ergometer exercise sessions (30min, 70% V<mml:mo>.</mml:mover>O2 peak ) followed by 5min of inactive recovery performed with (occlusion) or without (control) leg circulatory occlusion (bilateral thigh cuffs inflated to a suprasystolic pressure). HRR was assessed via HR reduction after 30, 60 and 300s of recovery (HRR30s, HRR60s and HRR300s), as well as by the analysis of short- and long-term time constants of HRR. cBRS was assessed by sequence technique and HRV by the root mean square residual and the root mean square of successive differences between adjacent RR intervals on subsequent 30s segments. Data were analysed using two- and three-way ANOVA. HRR60s and cBRS were significant and similarly reduced in both groups in the occlusion compared to the control session (combined values: 2010 vs. 269beatsmin(-1) and 2.11.2 vs. 3.22.4msmmHg(-1), respectively, P<0.05). HRR300s and HRV were also reduced in the occlusion session, although these reductions were significantly greater in HT compared to NT (-1611 vs. -8 +/- 15beatsmin(-1) for HRR300s, P<0.05). The results support the role of metaboreflex in HRR and suggest that increased metaboreflex sensitivity may partially explain the delayed HRR observed in HT men. (AU)

• FAPESP's process: 13/04997-0 - Heart rate recovery after exercise: regulatory mechanisms
• Grantee: Cláudia Lúcia de Moraes Forjaz
• Support type: Regular Research Grants
• FAPESP's process: 13/05519-4 - Heart rate recovery after exercise: regulatory mechanisms in normotensives and hypertensives
• Grantee: Tiago Peçanha de Oliveira
• Support type: Scholarships in Brazil - Doctorate