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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enhancement of chlorpromazine antitumor activity by Pluronics F127/L81 nanostructured system against human multidrug resistant leukemia

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de Mello, Joyce C. ; Moraes, Vivian W. R. ; Watashi, Carolina M. ; da Silva, Deyse C. ; Cavalcanti, Leide P. ; Franco, Margareth K. K. D. ; Yokaichiya, Fabiano ; de Araujo, Daniele R. ; Rodrigues, Tiago
Total Authors: 9
Document type: Journal article
Source: PHARMACOLOGICAL RESEARCH; v. 111, p. 102-112, SEP 2016.
Web of Science Citations: 5

The development of specific tyrosine kinase inhibitors (TKIs) revolutionized the treatment of chronic myeloid leukemia (CML). However, chemoresistance of tumor cells to TKIs has already been described, and several mechanisms account for the multidrug resistance (MDR) phenotypes, including the over expression of P-glycoprotein (P-gp). This decreases the rate of healing and complete tumor remission. Nanotechnological tools have been studied to allow advances in this field. Poloxamers (Pluronics) have been proposed as drug carriers to improve therapeutic efficacy and decrease side effects, even in cancer therapy, due to their ability to inhibit P-gp. Antipsychotic phenothiazines have been described as potent cytotoxic drugs against several types of tumor cells in vitro. Here, we show that nanostructured micellar systems containing the phenothiazine derivative chlorpromazine (CPZ) potentiated the cytotoxicity of free CPZ and increased the selectivity against CML tumor cells, demonstrating the pharmacological potential of these poloxamer-based nanostructured systems containing CPZ in cancer therapy. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/05099-5 - Study of the mechanisms of Thioridazine-Induced cell death in tumor cells: focus on signaling pathways and expression of Bcl-2 family proteins
Grantee:Vivian Werloger Rodrigues de Moraes
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/21433-7 - Nanostructured systems containing phenothiazines: effects on bioenergetics and mechanisms of death in tumor cells
Grantee:Joyce Cristine de Mello
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/12247-8 - New applications of phenothiazines and Palladacycles: nanostructured systems to the mechanistic study of death in tumor cells
Grantee:Tiago Rodrigues
Support type: Regular Research Grants