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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Propentofylline Prevents Sickness Behavior and Depressive-Like Behavior Induced by Lipopolysaccharide in Rats via Neuroinflammatory Pathway

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Author(s):
Moraes, Marcia M. T. ; Galvao, Marcella C. ; Cabral, Danilo ; Coelho, Cideli P. ; Queiroz-Hazarbassanov, Nicolle ; Martins, Maria F. M. ; Bondan, Eduardo F. ; Bernardi, Maria M. ; Kirsten, Thiago Berti
Total Authors: 9
Document type: Journal article
Source: PLoS One; v. 12, n. 1 JAN 5 2017.
Web of Science Citations: 12
Abstract

Recent studies have demonstrated the intimate relationship between depression and immune disturbances. Aware of the efficacy limits of existing antidepressant drugs and the potential anti-inflammatory properties of propentofylline, we sought to evaluate the use of propentofylline as a depression treatment. We used a rat model of depression induced by repetitive lipopolysaccharide (LPS) administrations. We have studied sickness behavior, by assessing daily body weight, open field behavior, and TNF-alpha plasmatic levels. Anxiety-like behavior (light-dark test), depressive-like behavior (forced swim test), plasmatic levels of the brain-derived neurotrophic factor (BDNF, depression biomarker), and central glial fibrillary acidic protein (GFAP) expression (an astrocyte biomarker) were also evaluated. LPS induced body weight loss, open field behavior impairments (decreased locomotion and rearing, and increased immobility), and increased TNF-alpha levels in rats, compared with control group. Thus, LPS induced sickness behavior. LPS also increased the immobility and reduced climbing in the forced swim test, when compared with the control group, i.e., LPS induced depressive-like behavior in rats. Propentofylline prevented sickness behavior after four days of consecutive treatment, as well as prevented the depressive-like behavior after five days of consecutive treatments. Propentofylline also prevented the increase in GFAP expression induced by LPS. Neither LPS nor propentofylline has influenced the anxiety and BDNF levels of rats. In conclusion, repetitive LPS administrations induced sickness behavior and depressive-like behavior in rats. Propentofylline prevented both sickness behavior and depressive-like behavior via neuroinflammatory pathway. The present findings may contribute to a better understanding and treatment of depression and associated diseases. (AU)

FAPESP's process: 14/25113-5 - Effects of propentofylline and lipopolysaccharide on sickness behavior, depressive-like behavior, and TNF-alpha plasma levels of rats
Grantee:Marcella Cristina Galvão
Support Opportunities: Scholarships in Brazil - Scientific Initiation