| Full text | |
| Author(s): |
Cazzo, Everton
;
Gestic, Martinho Antonio
;
Utrini, Murillo Pimentel
;
Pareja, Jose Carlos
;
Chaim, Elinton Adami
;
Geloneze, Bruno
;
Lazzarinibarreto, Maria Rita
;
Magro, Daniela Oliveira
Total Authors: 8
|
| Document type: | Journal article |
| Source: | ABCD-ARQUIVOS BRASILEIROS DE CIRURGIA DIGESTIVA-BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY; v. 29, n. 4, p. 257-259, OCT-DEC 2016. |
| Web of Science Citations: | 3 |
| Abstract | |
Background: The role of gut hormones in glucose homeostasis and weight loss achievement and maintenance after bariatric surgery appears to be a key point in the understanding of the beneficial effects observed following these procedures. Aim: To determine whether there is a correlation between the pre and postoperative levels of both GLP-1 and GLP-2 and the excess weight loss after Roux-en-Y gastric bypass (RYGB). Methods: An exploratory prospective study which enrolled 11 individuals who underwent RYGB and were followed-up for 12 months. GLP-1 and GLP-2 after standard meal tolerance test (MTT) were determined before and after surgery and then correlated with the percentage of excess loss (%EWL). Results: GLP-2 AUC presented a significant postoperative increase (945.3 +/- 449.1 vs. 1787.9 +/- 602.7; p=0.0037); GLP-1 AUC presented a non-significant trend towards increase after RYGB (709.6 +/- 320.4 vs. 1026.5 +/- 714.3; p=0.3808). Mean % EWL was 66.7 +/- 12.2%. There was not any significant correlation between both the pre and postoperative GLP-1 AUCs and GLP-2 AUCs and the % EWL achieved after one year. Conclusion: There was no significant correlation between the pre and postoperative levels of the areas under the GLP-1 and GLP-2 curves with the percentage of weight loss reached after one year. (AU) | |