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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo

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Bueno-Junior, Lezio S. ; Ruggiero, Rafael N. ; Rossignoli, Matheus T. ; Del Bel, Elaine A. ; Leite, Joao P. ; Uchitel, Osvaldo D.
Total Authors: 6
Document type: Journal article
Source: PHYSIOLOGICAL REPORTS; v. 5, n. 1 JAN 2017.
Web of Science Citations: 2

The knowledge on real-time neurophysiological effects of acetazolamide is still far behind the wide clinical use of this drug. Acetazolamide - a carbonic anhydrase inhibitor - has been shown to affect the neuromuscular transmission, implying a pH-mediated influence on the central synaptic transmission. To start filling such a gap, we chose a central substrate: hippocampal-prefrontal cortical projections; and a synaptic phenomenon: paired-pulse facilitation (a form of synaptic plasticity) to probe this drug's effects on interareal brain communication in chronically implanted rats. We observed that systemic acetazolamide potentiates the hippocampal-prefrontal paired-pulse facilitation. In addition to this field electrophysiology data, we found that acetazolamide exerts a net inhibitory effect on prefrontal cortical single-unit firing. We propose that systemic acetazolamide reduces the basal neuronal activity of the prefrontal cortex, whereas increasing the afferent drive it receives from the hippocampus. In addition to being relevant to the clinical and side effects of acetazolamide, these results suggest that exogenous pH regulation can have diverse impacts on afferent signaling across the neocortex. (AU)

FAPESP's process: 12/23918-0 - Synaptic plasticity of the hippocampus-prefrontal cortex pathway and its relations with behavioral and molecular changes in rats submitted to febrile seizures during development
Grantee:Rafael Naime Ruggiero
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/17882-4 - Drug-resistant epilepsies: diagnostic challenges, associated comorbidities and new experimental approaches
Grantee:João Pereira Leite
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/06123-4 - Hippocampal-prefrontal synaptic plasticity in awake rats: effects of thalamic stimulation during natural sleep and implications for memory consolidation
Grantee:Lézio Soares Bueno Júnior
Support type: Scholarships in Brazil - Post-Doctorate