Nonverbal behaviors are associated with increased vagal activity in major depressive disorder: Implications for the polyvagal theory

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Fernandes, Raquel A. ; Fiquer, Juliana T. ; Gorenstein, Clarice ; Razza, Lais Boralli ; Fraguas, Jr., Renerio ; Borrione, Lucas ; Bensenor, Isabela M. ; Lotufo, Paulo A. ; Dantas, Eduardo Miranda ; Carvalho, Andre F. ; Brunoni, Andre R.

• Document type: Journal article
• Source: Journal of Affective Disorders; v. 209, p. 18-22, FEB 2017.
• Web of Science Citations: 1

Abstract

Background: Major depressive disorder (MDD) is associated with impairments in nonverbal behaviors (NVBs) and vagal activity. The polyvagal theory proposes that vagal activity regulates heart rate and NVBs by modulating a common anatomically and neurophysiologically discrete social engagement system. However, the association between these putative endophenotypes has not yet been explored. We hypothesize that in MDD, NVBs indicating positive affects and social interest and those indicating negative feelings and social disinterest could be associated with different patterns of vagal activity. Methods: For this cross-sectional study we recruited 50 antidepressant-free participants with moderate-to-severe MDD. Vagal activity was indexed by heart rate variability (HRV) measures, and positive and negative nonverbal behaviors (NVBs) by a validated ethogram. Associations between NVBs and HRV were explored by bivariate analyses and multivariable models were adjusted by age, gender, depression severity, and self-reported positive and negative affects. Results: HRV measures indicative of higher vagal activity were positively correlated with positive NVBs exhibited during the clinical interview. Conversely, NVBs related to negative affects, low energy and social disinterest were not associated with HRV. Limitations: Absence of a control group. Conclusions: The findings highlight that the examined depression endophenotypes (nonverbal behaviors and vagal activity) are related, shedding light on MDD pathophysiology in the context of the polyvagal theory. (AU)

• FAPESP's process: 14/20799-6 - Relation between heart rate variability and non-verbal behavior in depression based on Polyvagal theory
• Grantee: Raquel Albano Fernandes
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 12/50879-6 - Indicators of expressiveness and emotional processing in depression
• Grantee: Clarice Gorenstein
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/51732-6 - Non-verbal expressiveness in depression: discrimination between patients and healthy controls, clinical subgroups identification and prognostic and clinical improvement assessments through nonverbal behavioral indicators
• Grantee: Juliana Teixeira Fiquer
• Support Opportunities: Scholarships in Brazil - Post-Doctoral