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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymorphisms in apoptosis-related genes in cutaneous melanoma prognosis: sex disparity

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Author(s):
Oliveira, Cristiane ; Lourenco, Gustavo Jacob ; Rinck-Junior, Jose Augusto ; de Moraes, Aparecida Machado ; Passos Lima, Carmen Silvia
Total Authors: 5
Document type: Journal article
Source: MEDICAL ONCOLOGY; v. 34, n. 2 FEB 2017.
Web of Science Citations: 0
Abstract

Cutaneous melanoma (CM) cells are resistant to apoptosis, and steroid hormones are involved in this process through regulation of TP53, MDM2, BAX, and BCL2 expression. We analyzed herein sex differences in outcomes of CM patients associated with TP53 c.215G>C, MDM2 c.309T>G, BAX c.-248G>A, and BCL2 c.-717C>A polymorphisms. DNA from 121 men and 116 women patients was analyzed by polymerase chain reaction and enzymatic digestion assays. At 60 months of follow-up, shorter progression-free survival (PFS) was seen in males with MDM2 GG + BCL2 AA (20.0 vs. 62.6%, P = 0.0008) genotype. Men carriers of the genotype had poor PFS (HR 3.78, 95% CI 1.30-11.0) than others. For women, shorter PFS was associated with TP53 GC or CC (61.4 vs. 80.8%, P = 0.01) and TP53 GC or CC + MDM2 TG or GG (59.1 vs. 85.4%, P = 0.01) genotypes at the same time. Women carriers of the genotypes had poor PFS (HR 2.46, 95% CI 1.19-5.09; HR 9.49, 95% CI 1.14-78.50) than others, respectively. Our data present, for the first time, preliminary evidence that inherited abnormalities on TP53, MDM2 and BCL2 genes, enrolled in apoptosis pathways, have a pivotal role in differences of outcomes in women and men with CM. (AU)

FAPESP's process: 10/18904-5 - The influence of the p53 arg72pro, Mdm2 t309g, Bcl2 c938a and Bax g248a, genetic polymorphisms, involved in induction of apoptosis, in the malignant melanoma risk
Grantee:Carmen Silvia Passos Lima
Support Opportunities: Regular Research Grants
FAPESP's process: 09/12602-0 - Influence of the polymorphisms TP53 arg72pro, MDM2 t309g, Bcl2 c938a e Bax g248a, related with celular apoptosis, in the susceptibility of malignant melanoma
Grantee:Cristiane de Oliveira
Support Opportunities: Scholarships in Brazil - Master