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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Infections with multiple high-risk HPV types are associated with high-grade and persistent low-grade intraepithelial lesions of the cervix

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De Brot, Louise ; Pellegrini, Bruno ; Moretti, Sabrina Teixeira ; Carraro, Dirce Maria ; Soares, Fernando Augusto ; Rocha, Rafael Malagoli ; Baiocchi, Glauco ; da Cunha, Isabela Werneck ; de Andrade, Victor Piana
Total Authors: 9
Document type: Journal article
Source: CANCER CYTOPATHOLOGY; v. 125, n. 2, p. 138-143, FEB 2017.
Web of Science Citations: 7

BACKGROUNDInfections with multiple human papillomavirus (HPV) types (mHPV) in Papanicolaou tests have been reported but the histologic correlation and clinical meaning remains debatable. METHODSThe authors prospectively tested 37 HPV types using the Linear Array HPV Genotyping Test and correlated the results to cytology and histology findings in 260 women evaluated from June 2009 to October 2011 and followed for up to 60 months. RESULTSHPV was detected in 148 of 235 samples (63%) and high-risk HPV was detected in 132 samples (56%). mHPV infection was found to be twice as common as single HPV (sHPV) infection and was detected more frequently in low-grade squamous intraepithelial lesion (LSIL) (48 of 83 samples {[}58%]) and high-grade squamous intraepithelial lesion or invasive carcinoma (HSIL+(26 of 47 samples {[}55%]) compared with other categories (P<.001). Of 34 LSIL/cervical intraepithelial neoplasia 1 (CIN1) index cases, 13 of 21 patients with mHPV (61.9%) persisted on CIN1, whereas no histologic abnormality was detected during follow-up in all 12 patients with sHPV infection (high risk or low risk) (P<.001). Eighteen of 20 patients with HSIL/cervical intraepithelial neoplasia 2 (CIN2) (90%) and high-risk mHPV persisted on HSIL+/CIN2+whereas 6 of 11 patients with sHPV infection did not demonstrate HSIL+/CIN2+on follow-up (54.5%) (P=.066). Approximately 40% of women with HSIL were infected by high-risk HPV types other than types 16 or 18. CONCLUSIONSHigh-risk mHPV infection identified patients with persistent LSIL/CIN1 and may to help identify patients at higher risk of disease progression to HSIL+/CIN2+. Longer follow-up will clarify the role of mHPV testing in patient care. Cancer Cytopathol 2017;125:138-143. (c) 2016 American Cancer Society. (AU)

FAPESP's process: 10/17645-6 - Morphometric, immunocytochemistry and molecular analysis of cervicovaginal cytology with atypia of undetermined significance
Grantee:Isabela Werneck da Cunha
Support Opportunities: Regular Research Grants