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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lactococcus garvieae outbreaks in Brazilian farms Lactococcosis in Pseudoplatystoma sp - development of an autogenous vaccine as a control strategy

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Author(s):
Fukushima, H. C. S. ; Leal, C. A. G. ; Cavalcante, R. B. ; Figueiredo, H. C. P. ; Arijo, S. ; Morinigo, M. A. ; Ishikawa, M. ; Borra, R. C. ; Ranzani-Paiva, M. J. T.
Total Authors: 9
Document type: Journal article
Source: JOURNAL OF FISH DISEASES; v. 40, n. 2, p. 263-272, FEB 2017.
Web of Science Citations: 7
Abstract

This study evaluated the control of streptococcosis outbreaks in Brazil, isolated from diseased sorubim and identified as Lactococcus garvieae by genetic sequencing. This report determined the potential for lactococcosis control in sorubim Pseudoplatystoma sp. with two vaccines: an aqueous-based, whole-cell inactivated vaccine (bacterin) and an oil-adjuvanted bacterin. Their efficacy was evaluated at 30 days post-vaccination (d.p.v.) by challenge with L. garvieae, and the antibody production response at 15, 30 and 60 d.p.v. and the non-specific immune response were compared amongst treatments. High protection levels (P < 0.05) were achieved with the oil-adjuvanted vaccine with a relative percentage survival value of 81.7% at 30 d.p.v. Additionally, the oil-adjuvanted vaccine increased the immunogenicity of the bacterin as indicated by greater agglutination antibody titres from 15 until 60 d.p.v. This is the first report of a positive effect of vaccine administration on the specific immunity of sorubim, and the study showed that a specific antibody plays an important role in sorubim defence against lactococcosis because the innate immune responses were similar in all of the studied animals. These results demonstrated that oil-adjuvanted vaccine can be an effective alternative for the protection of sorubim from L. garvieae disease. (AU)

FAPESP's process: 10/16149-5 - Vaccination of surubin Pseudoplatystoma reticulatum x Pseudoplatystoma corruscans against Lactococcus garvieae bacteria.
Grantee:Hirla Costa Silva Fukushima
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/07852-0 - Vaccination of pintado Pseudoplatystoma corruscans juveniles against Lactococcus garvieae bacteria
Grantee:Maria José Tavares Ranzani de Paiva
Support Opportunities: Regular Research Grants