Fungal pathogenicity: environmental effects, immune response and vaccine modulatio...
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Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
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| Author(s): |
Travassos, Luiz R.
;
Taborda, Carlos P.
Total Authors: 2
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| Document type: | Journal article |
| Source: | FRONTIERS IN IMMUNOLOGY; v. 8, MAR 10 2017. |
| Web of Science Citations: | 4 |
| Abstract | |
Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South America; Histoplasma capsulatum, Coccidioides posadasii, and Coccidioides immitis, and the Sporothrix spp. complex are other important pathogens. Associated with dimorphic fungi other important infections are caused by yeast such as Candida spp. and Cryptococcus spp. or mold such as Aspergillus spp., which are also fungal agents of deadly infections. Nowadays, the actual tendency of therapy is the development of a pan-fungal vaccine. This is, however, not easy because of the complexity of eukaryotic cells and the particularities of different species and isolates. Albeit there are several experimental vaccines being studied, we will focus mainly on peptide vaccines or epitopes of T-cell receptors inducing protective fungal responses. These peptides can be carried by antibody inducing beta-( 1,3)-glucan oligo or polysaccharides, or be mixed with them for administration. The present review discusses the efficacy of linear peptide epitopes in the context of antifungal immunization and vaccine proposition. (AU) | |
| FAPESP's process: | 10/51423-0 - Bioactive peptides and peptidases: biological and immunobiological activities in infectious diseases and cancer |
| Grantee: | Luiz Rodolpho Raja Gabaglia Travassos |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/08730-6 - Fungal pathogenicity: environmental effects, immune response and vaccine modulation in the Brazilian endemic mycoses paracoccidioidomycosis and histoplasmosis |
| Grantee: | Carlos Pelleschi Taborda |
| Support type: | Research Projects - Thematic Grants |