Expression of human endogenous retrovirus K and W in babies

Author(s)

Nali, L. H. S. ; Oliveira, A. C. S. ; Alves, D. O. ; Caleiro, G. S. ; Nunes, C. F. ; Gerhardt, D. ; Succi, R. C. M. ; Romano, Camila M. ; Machado, D. M.

• Document type: Journal article
• Source: ARCHIVES OF VIROLOGY; v. 162, n. 3, p. 857-861, MAR 2017.
• Web of Science Citations: 2

Abstract

Here we determined the relative expression of HERV-K and W proviruses in HIV infected and non-infected mothers as well as their respective babies up to 1 year-old. HIV-infected mothers, their babies and uninfected control groups presented expression of both HERV-K and HERV-W with relatively high frequency. While the level of HERV-K expression was similar among groups, the level of HERV-W expression in HIV-infected mothers was four-fold higher than the uninfected mothers from the control group (p < 0.01). HERV-W was down regulated in HIV-exposed babies in comparison to non-exposed babies. To our knowledge, this is the first report of HERV transcriptional activity in babies from 0-1 year-old. (AU)

• FAPESP's process: 12/15381-7 - Characterization of adaptive mutations in dengue virus serotype 2 (DENV2) cultured in different systems using high-throughput sequencing
• Grantee: Camila Malta Romano
• Support Opportunities: Regular Research Grants