Pharmacological strategies for the prevention of the respiratory abnormalities in ...
| Full text | |
| Author(s): |
Silva, Carlos A.
;
Vicente, Mariane C.
;
Tenorio-Lopes, Luana
;
Soliz, Jorge
;
Gargaglioni, Luciane H.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | Respiratory Physiology & Neurobiology; v. 236, p. 11-18, FEB 2017. |
| Web of Science Citations: | 3 |
| Abstract | |
The Locus coeruleus (LC) is a pontine area that contributes to the CO2/pH chemosensitivity. LC cells express erythropoietin (Epo) receptors (EpoR), and Epo in the brainstem is a potent normoxic and hypoxic respiratory stimulant. However, a recent study showed that the intra-cisternal injection (ICI) of Epo antagonist does not alter the hypercapnic ventilatory response in mice. As ICI leads to a widespread dispersal of the product throughout the brainstem, in this work we evaluated the specific impact of Epo in the LC-mediated ventilatory response to CO2 (by whole body plethysmography) in juvenile male Wistar rats. Normocapnic and hypercapnic ventilation were evaluated before and after unilateral microinjection of Epo (1 ng/100 nL) into the LC. To evaluate the long-term effect of Epo, the HcVR was re-evaluated 24h later. Our results show that Epo attenuates the hypercapnic ventilation. We conclude that Epo in the LC tunes the hypercapnia-induced hyperpnea. (C) 2016 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 12/19966-0 - Cardiorespiratory pattern and awake-sleep state in male and female rats exposed to fluoxetine during prenatal period |
| Grantee: | Luciane Helena Gargaglioni Batalhão |
| Support type: | Regular Research Grants |