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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats

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Author(s):
Silva, Carlos A. ; Vicente, Mariane C. ; Tenorio-Lopes, Luana ; Soliz, Jorge ; Gargaglioni, Luciane H.
Total Authors: 5
Document type: Journal article
Source: Respiratory Physiology & Neurobiology; v. 236, p. 11-18, FEB 2017.
Web of Science Citations: 3
Abstract

The Locus coeruleus (LC) is a pontine area that contributes to the CO2/pH chemosensitivity. LC cells express erythropoietin (Epo) receptors (EpoR), and Epo in the brainstem is a potent normoxic and hypoxic respiratory stimulant. However, a recent study showed that the intra-cisternal injection (ICI) of Epo antagonist does not alter the hypercapnic ventilatory response in mice. As ICI leads to a widespread dispersal of the product throughout the brainstem, in this work we evaluated the specific impact of Epo in the LC-mediated ventilatory response to CO2 (by whole body plethysmography) in juvenile male Wistar rats. Normocapnic and hypercapnic ventilation were evaluated before and after unilateral microinjection of Epo (1 ng/100 nL) into the LC. To evaluate the long-term effect of Epo, the HcVR was re-evaluated 24h later. Our results show that Epo attenuates the hypercapnic ventilation. We conclude that Epo in the LC tunes the hypercapnia-induced hyperpnea. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/19966-0 - Cardiorespiratory pattern and awake-sleep state in male and female rats exposed to fluoxetine during prenatal period
Grantee:Luciane Helena Gargaglioni Batalhão
Support type: Regular Research Grants