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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of a salt drug with improved solubility: Ethionamide nitrate

Full text
Author(s):
Diniz, Luan F. ; Carvalho, Jr., Paulo S. ; de Melo, Cristiane C. ; Ellena, Javier
Total Authors: 4
Document type: Journal article
Source: Journal of Molecular Structure; v. 1137, p. 119-125, JUN 5 2017.
Web of Science Citations: 2
Abstract

To avoid drug resistance, an adequate tuberculosis treatment should include not only a first-line drug but also at least one second-line drug such as, for example, Ethionamide (ETH). However, the dissolution rate and oral absorption of ETH is highly limited by its low aqueous solubility. Considering that a salt is in general more soluble than its parent compound, herein we depicted a new supramolecular modification of ETH, an Ethionamide nitrate salt (ETHNO3). This salt is the first ETH structure that has been crystallized with four independent ionic pairs (ETH+NOT3-) in the asymmetric unit. In addition to the structural study, the salt formation was also identified on the FT-IR and FT-Raman spectra. The thermal behavior of ETHNO3 was also investigated here together with its solubility profile in three dissolution media (purified water, pH 4.0 and 7.0). (C) 2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 15/25694-0 - Obtaining, characterization and evaluation of novel crystalline solid forms of drugs used treatment of tuberculosis
Grantee:Luan Farinelli Diniz
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/05616-7 - Solid-state characterization of anticonvulsant and antidepressant phamaceutical compounds: Design of new crystal forms.
Grantee:Paulo de Sousa Carvalho Júnior
Support Opportunities: Scholarships in Brazil - Doctorate