NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes

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Tasic, Ljubica ; de Moraes Pontes, Joao Guilherme ; de Souza, Rafael Nogueira ; Marreiro Brasil, Antonio Jadson ; de Faria Cruz, Guilherme Crispim ; Asevedo, Elson ; Dal Mas, Caroline ; Poppi, Ronei Jesus ; Brietzke, Elisa ; Furuie Hayashi, Mirian Akemi ; Tavares Lacerda, Acioly Luiz

• Document type: Journal article
• Source: CHEMISTRYSELECT; v. 2, n. 10, p. 2927-2930, APR 3 2017.
• Web of Science Citations: 3

Abstract

Crack-cocaine abuse and dependence is a severe public health problem. Sometimes, the crack-cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crackcocaine use can easily be detected in smokers by urine or blood tests, after some time, cocaine biomarkers become untraceable. In addition, schizophrenia diagnosis is limited to clinical interviews, while precise clinical tests for this mental disorder remain unknown. Employing metabolomics based on NMR spectroscopy, herein, we showed that blood serum metabolites might be used for discrimination between crackcocaine users and schizophrenia patients groups. These two groups showed the greatest differences in around eleven keymetabolites. Moreover, seven possible peripheral metabolites might be enough for differentiation of crack-cocaine users and healthy controls. These results may contribute to a better understanding of crack-cocaine biochemical effects, and enable more precise diagnosis when crack-cocaine biomarkers, methylecgonidine or ecgonidine, are absent from the urine or blood of crack-cocaine users. (AU)

• FAPESP's process: 14/18938-8 - Metabolomic profiling of severe mental disorders using Nuclear Magnetic Ressonance (NMR)
• Grantee: Ljubica Tasic
• Support type: Regular Research Grants