CHARACTERIZATION OF CIRCADIAN CLOCK PROTEINS Per1, Cry1, and MELATONIN RECEPTORS I...
Day/night differences in protein expression in the auditory brainstem centers of t...
| Full text | |
| Author(s): |
Pinato, Luciana
;
Ramos, Dayane
;
Hataka, Alessandre
;
Rossignoli, Patricia S.
;
Granado Junior, Marcos Donisete
;
Mazzetto, Marina Cardoso
;
Campos, Leila M. G.
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Journal of Chemical Neuroanatomy; v. 81, p. 10-17, APR 2017. |
| Web of Science Citations: | 7 |
| Abstract | |
Melatonin is involved in the temporal organization of several physiological and behavioral events, controlled by hypothalamic nuclei, like sleep, feeding, reproduction and metabolic modulation and acts through two types of high-affinity G protein-coupled membrane receptors: MT1 and MT2. This study aimed to investigate the expression of MT1 and MT2 receptors proteins in four hypothalamic nuclei, i.e., SCN, supraoptic (SON), paraventricular (PVN) and anteroventral periventricular nuclei (AVPV), of the diurnal primate Sapajus apella using immunohistochemistry. Since these areas are involved in the expression of biological rhythms, they are candidates to have variations in their neurochemistry, so the MT1 and MT2 expression has been analyzed at a point in light and another in the dark phase. Both receptors were found to have day/night differences in the four hypothalamic nuclei with an apparent inverse expression in the SCN compared with the other areas. These differences could be related to the idea that the individual should be prepared to respond by different ways to melatonin signal within the several processes and can contribute to the efficacy of melatonin ligands or melatonin in therapies. (C) 2017 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 11/51495-4 - Induction of melatonin synthesis by glia and neurons in injured central nervous system |
| Grantee: | Luciana Pinato |
| Support Opportunities: | Research Grants - Young Investigators Grants |