| Full text | |
| Author(s): |
Esteves, I. M.
;
Lopes-Aguiar, C.
;
Rossignoli, M. T.
;
Ruggiero, R. N.
;
Broggini, A. C. S.
;
Bueno-Junior, L. S.
;
Kandratavicius, L.
;
Monteiro, M. R.
;
Romcy-Pereira, R. N.
;
Leite, J. P.
Total Authors: 10
|
| Document type: | Journal article |
| Source: | Neuroscience; v. 353, p. 87-97, JUN 14 2017. |
| Web of Science Citations: | 6 |
| Abstract | |
Brain glucose metabolism is altered in sporadic Alzheimer's disease (sAD), whose pathologies are reproduced in rodents by intracerebroventricular (icy) infusion of streptozotocin (STZ) in subdiabetogenic doses. The icv-STZ model also culminates in central cholinergic dysfunctions, which in turn are known to underlie both the sAD cognitive decline, and synaptic plasticity impairments. Considering the cognitive-enhancing potential of chronic nicotine (Nic), we investigated whether it attenuates icv-STZ-induced impairments in recognition memory and synaptic plasticity in a cognition-relevant substrate: the hippocampal CA1-medial prefrontal cortex (mPFC) pathway. Rats treated with icv-STZ were submitted to a chronic Nic regime, and were evaluated for recognition memory. We then examined long-term potentiation (LTP), paired-pulse facilitation (PPF) under urethane anesthesia, and brains were also evaluated for hippocampus-mPFC cell density. We found that Nic treatment prevents icv-STZ-induced disruptions in recognition memory and LTP. STZ did not precipitate neuronal death, while Nic alone was associated with higher neuronal density in CA1 when compared to vehicle-injected animals. Through combining behavioral, neurophysiological, and neuropathological observations into the Nic-STZ interplay, our study reinforces that cholinergic treatments are of clinical importance against early-stage Alzheimer's disease and mild cognitive impairments. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 12/23918-0 - Synaptic plasticity of the hippocampus-prefrontal cortex pathway and its relations with behavioral and molecular changes in rats submitted to febrile seizures during development |
| Grantee: | Rafael Naime Ruggiero |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/25275-8 - Optogenetic investigation of hippocampal ripples influence on prefrontal circuits during contextual fear memory formation |
| Grantee: | Cleiton Lopes Aguiar |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 14/18211-0 - Characterization and optogenetic control of the hippocampus-medial prefrontal cortex interplay during the post-learning sleep in an experimental model of early-life seizures |
| Grantee: | Cleiton Lopes Aguiar |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |