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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

CHRONIC NICOTINE ATTENUATES BEHAVIORAL AND SYNAPTIC PLASTICITY IMPAIRMENTS IN A STREPTOZOTOCIN MODEL OF ALZHEIMER'S DISEASE

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Author(s):
Esteves, I. M. ; Lopes-Aguiar, C. ; Rossignoli, M. T. ; Ruggiero, R. N. ; Broggini, A. C. S. ; Bueno-Junior, L. S. ; Kandratavicius, L. ; Monteiro, M. R. ; Romcy-Pereira, R. N. ; Leite, J. P.
Total Authors: 10
Document type: Journal article
Source: Neuroscience; v. 353, p. 87-97, JUN 14 2017.
Web of Science Citations: 6
Abstract

Brain glucose metabolism is altered in sporadic Alzheimer's disease (sAD), whose pathologies are reproduced in rodents by intracerebroventricular (icy) infusion of streptozotocin (STZ) in subdiabetogenic doses. The icv-STZ model also culminates in central cholinergic dysfunctions, which in turn are known to underlie both the sAD cognitive decline, and synaptic plasticity impairments. Considering the cognitive-enhancing potential of chronic nicotine (Nic), we investigated whether it attenuates icv-STZ-induced impairments in recognition memory and synaptic plasticity in a cognition-relevant substrate: the hippocampal CA1-medial prefrontal cortex (mPFC) pathway. Rats treated with icv-STZ were submitted to a chronic Nic regime, and were evaluated for recognition memory. We then examined long-term potentiation (LTP), paired-pulse facilitation (PPF) under urethane anesthesia, and brains were also evaluated for hippocampus-mPFC cell density. We found that Nic treatment prevents icv-STZ-induced disruptions in recognition memory and LTP. STZ did not precipitate neuronal death, while Nic alone was associated with higher neuronal density in CA1 when compared to vehicle-injected animals. Through combining behavioral, neurophysiological, and neuropathological observations into the Nic-STZ interplay, our study reinforces that cholinergic treatments are of clinical importance against early-stage Alzheimer's disease and mild cognitive impairments. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/23918-0 - Synaptic plasticity of the hippocampus-prefrontal cortex pathway and its relations with behavioral and molecular changes in rats submitted to febrile seizures during development
Grantee:Rafael Naime Ruggiero
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/18211-0 - Characterization and optogenetic control of the hippocampus-medial prefrontal cortex interplay during the post-learning sleep in an experimental model of early-life seizures
Grantee:Cleiton Lopes Aguiar
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/25275-8 - Optogenetic investigation of hippocampal ripples influence on prefrontal circuits during contextual fear memory formation
Grantee:Cleiton Lopes Aguiar
Support type: Scholarships abroad - Research Internship - Post-doctor