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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Differential Pattern of Cerebellar Atrophy in Tremor-Predominant and Akinetic/Rigidity-Predominant Parkinson's Disease

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Piccinin, Camila Callegari ; Campos, Lidiane Soares ; Guimaraes, Rachel Paes ; Piovesana, Luiza Gonzaga ; Arci dos Santos, Maria Cristina ; Azevedo, Paula Christina ; Campos, Brunno Machado ; Ribeiro de Rezende, Thiago Junqueira ; Amato-Filho, Augusto ; Cendes, Fernando ; D'Abreu, Anelyssa
Total Authors: 11
Document type: Journal article
Source: CEREBELLUM; v. 16, n. 3, p. 623-628, JUN 2017.
Web of Science Citations: 7
Abstract

Parkinson's disease (PD) is an akinetic-rigid disorder characterized by basal ganglia dysfunction and a possible cerebello-thalamo-cortical circuit involvement. This study aims to investigate the pattern of cerebellar involvement in PD and to assess whether it correlates with clinical parameters. MRI scans were acquired from 50 healthy controls (HC) and 63 patients; 44 were classified as tremor-predominant-PD (PDT) and 19 as akinetic/rigidity-predominant-PD (PDAR). We designed an analysis of covariance including the three groups and contrasted as follows: (1) all 63 PD vs HC, (2) PDT vs HC, (3) PDAR vs HC, and (4) PDT vs PDAR. For a precise evaluation of the cerebellum, we used the SUIT tool for voxel-based morphometry. Applying p = 0.001 and extent threshold = 20 voxels, the overall PD group vs HC showed decreased gray matter (GM) in the left lobules VI and crus I. The PDT group showed decreased cerebellar GM when compared with HC at left lobules VI, VIIb, and VIIIa; at right lobules Crus I, VIIb, and VIIIb; and vermal lobules VI and VIIIa. When compared with PDAR, PDT also showed a decrease in the left lobules VIIIa (p < 0.001). There were small clusters of both positive and negative correlation between disease duration and PDT group. The PDAR group showed no cerebellar changes. Our findings support the growing evidence of cerebellar involvement in the pathogenesis of the resting tremor. (AU)

FAPESP's process: 13/02660-8 - Infratentorial Structures analysis in Pakinson Disease
Grantee:Camila Callegari Piccinin
Support Opportunities: Scholarships in Brazil - Scientific Initiation