| Full text | |
| Author(s): |
Clavijo-Salomon, Maria A.
;
Bergami-Santos, Patricia C.
;
Barbuto, Jose Alexandre M.
Total Authors: 3
|
| Document type: | Journal article |
| Source: | Immunotherapy; v. 9, n. 4, p. 319-329, MAR 2017. |
| Web of Science Citations: | 3 |
| Abstract | |
With the enormous and growing interest in the clinical application of immunotherapy, we are currently facing the need to accurately monitor the immune function of cancer patients. Here, we describe changes in the immune status of a patient with metastatic type-2-papillary renal cell carcinoma, before and after surgery and subsequent immunotherapy with a dendritic cell-tumor cell hybrid vaccine. Through the accurate assessment of monocyte-derived dendritic cells (Mo-DCs) function, we show that Mo-DCs were freed from tumor-induced maturation blockage by tumor resection surgery, while Mo-DCs-tumor induced suppression and anergy were only interrupted by the vaccination treatment. Our data suggest that the evaluation of Mo-DCs' function may provide a powerful and precise tool to monitor immune restoration in cancer patients. (AU) | |
| FAPESP's process: | 11/05331-0 - Study of the effect of natural killer cells on the in vitro differentiation of monocytes into dendritic cells in cancer patients |
| Grantee: | Maria Alejandra Clavijo Salomón |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 09/54599-5 - Dendritic cells: integrative elements of the immune system - an applied approach |
| Grantee: | Jose Alexandre Marzagão Barbuto |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 12/23478-0 - Effect of Natural Killer cells on the in vitro differentiation of monocytes into dendritic cells in cancer patients: study of the mechanisms involved |
| Grantee: | Maria Alejandra Clavijo Salomón |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |