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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Both N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats

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Author(s):
Adami, Mariane B. ; Barretto-de-Souza, Lucas ; Duarte, Josiane O. ; Almeida, Jeferson ; Crestani, Carlos C.
Total Authors: 5
Document type: Journal article
Source: JOURNAL OF PSYCHOPHARMACOLOGY; v. 31, n. 6, p. 674-681, JUN 2017.
Web of Science Citations: 7
Abstract

The bed nucleus of the stria terminalis (BNST) is a forebrain structure that has been implicated on cardiovascular responses evoked by emotional stress. However, the local neurochemical mechanisms mediating the BNST control of stress responses are not fully described. In our study we investigated the involvement of glutamatergic neurotransmission within the BNST in cardiovascular changes evoked by acute restraint stress in rats. For this study, we investigated the effects of bilateral microinjections of selective antagonists of either N-methyl-D-aspartate (NMDA) or non-NMDA glutamate receptors into the BNST on the arterial pressure and heart rate increase and the decrease in tail skin temperature induced by acute restraint stress. Microinjection of the selective NMDA glutamate receptor antagonist LY235959 (1 nmol/100 nL) into the BNST decreased the tachycardiac response to restraint stress, without affecting the arterial pressure increase and the drop in skin temperature. Bilateral BNST treatment with the selective non-NMDA glutamate receptor NBQX (1 nmol/100 nL) decreased the heart rate increase and the fall in tail skin temperature, without affecting the blood pressure increase. These findings indicate a facilitatory influence of BNST glutamatergic neurotransmission via coactivation of local NMDA and non-NMDA receptors on the tachycardiac response to stress, whereas control of sympathetic-mediated cutaneous vasoconstriction is selectively mediated by local non-NMDA glutamate receptors. (AU)

FAPESP's process: 12/14376-0 - Comparison of the effect of two protocols of chronic stress in cardiovascular and autonomic functions in rats
Grantee:Carlos Cesar Crestani
Support Opportunities: Regular Research Grants
FAPESP's process: 15/05922-9 - Study of the participation of CRF neurotransmission in the bed nucleus of the stria terminalis in cardiovascular changes evoked by stress: interaction with the NMDA receptor/nitric oxide / guanilil cycles / protein kinase g signaling pathway?
Grantee:Carlos Cesar Crestani
Support Opportunities: Regular Research Grants