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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular and Genetic Aspects of Congenital Isolated Hypogonadotropic Hypogonadism

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Author(s):
Lima Amato, Lorena Guimaraes ; Latronico, Ana Claudia ; Gontijo Silveira, Leticia Ferreira
Total Authors: 3
Document type: Journal article
Source: ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA; v. 46, n. 2, p. 283+, JUN 2017.
Web of Science Citations: 4
Abstract

Congenital isolated hypogonadotropic hypogonadism (IHH) is a clinically and genetically heterogenous disorder characterized by abnormal synthesis, secretion, or action of gonadotropin-releasing hormone, a key hypothalamic decapeptide that orchestrates the reproductive axis. Several modes of inheritance have been identified. A growing list of causative genes has been implicated in the molecular pathogenesis of syndromic and nonsyndromic IHH, largely contributing for better understanding the complex neuroendocrine control of reproduction. This article summarizes the great advances of molecular genetics of IHH and pointed up the heterogeneity and complexity of the genetic basis of this condition. (AU)

FAPESP's process: 13/03236-5 - New approaches and methodologies in molecular-genetic studies of growth and pubertal development disorders
Grantee:Alexander Augusto de Lima Jorge
Support type: Research Projects - Thematic Grants