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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus

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de Souza, Lucas Canto ; Provensi, Gustavo ; Vullo, Daniela ; Carta, Fabrizio ; Scozzafava, Andrea ; Costa, Alessia ; Schmidt, Scheila Daiane ; Passani, Maria Beatrice ; Supuran, Claudiu T. ; Blandina, Patrizio
Total Authors: 10
Document type: Journal article
Source: Neuropharmacology; v. 118, p. 148-156, MAY 15 2017.
Web of Science Citations: 30

Rats injected with by D-phenylalanine, a carbonic anhydrase (CA) activator, enhanced spatial learning, whereas rats given acetazolamide, a CA inhibitor, exhibited impairments of fear memory consolidation. However, the related mechanisms are unclear. We investigated if CAs are involved in a non-spatial recognition memory task assessed using the object recognition test (ORT). Systemic administration of acetazolamide to male CD1 mice caused amnesia in the ORT and reduced CA activity in brain homogenates, while treatment with D-phenylalanine enhanced memory and increased CA activity. We provided also the first evidence that D-phenylalanine administration rapidly activated extracellular signal regulated kinase (ERK) pathways, a critical step for memory formation, in the cortex and the hippo campus, two brain areas involved in memory processing. Effects elicited by D-phenylalanine were completely blunted by co-administration of acetazolamide, but not of 1-N-(4-sulfamoylphenyl-ethyl)2,4,6-trimethylpyridinium perchlorate ((C18).) a CA inhibitor that, differently from acetazolamide, does not cross the blood brain barrier. Our results strongly suggest that brain but not peripheral CAs activation potentiates memory as a result of ERK pathway enhanced activation. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/05838-0 - The evaluation between histaminergic and cholinergic neurotransmission on object recognition and emotional memory
Grantee:Lucas Canto de Souza
Support type: Scholarships abroad - Research Internship - Doctorate