Prevalence of Helicobacter pylori infection in an indigenous community in São Paulo and associated factors: cross-sectional study

Author(s)

da Silva Roque, Juliana Rejane ; Machado, Rodrigo Strehl ; Rodrigues, Douglas ; Rech, Patricia ; Kawakam, Elisabete

• Document type: Journal article
• Source: São Paulo Medical Journal; v. 135, n. 2, p. 140-145, MAR-APR 2017.
• Web of Science Citations: 3

Abstract

ABSTRACT CONTEXT AND OBJECTIVE: The prevalence of Helicobacter pylori infection is unevenly distributed among different populations. The aim here was to evaluate the factors associated with Helicobacter pylori infection among children up to five years of age living in a high-risk community. DESIGN AND SETTING: Cross-sectional study in an indigenous community of Guarani Mbya ethnicity, Tekoa Ytu and Tekoa Pyau villages, Jaraguá district, city of São Paulo (SP), Brazil. METHODS: 74 children aged 0.4 to 4.9 years (mean 2.9 ± 1.3 years; median 3.1), and 145 family members (86 siblings, 43 mothers and 16 fathers) were evaluated for Helicobacter pylori infection using the validated 13C-urea breath test. Clinical and demographic data were collected. RESULTS: The prevalence was 8.3% among children aged 1-2 years and reached 64.3% among those aged 4-5 years (P = 0.018; overall 31.1%). The prevalence was 76.7% among siblings and 89.8% among parents. There was a negative association with previous use of antibiotics in multivariate analysis adjusted for age (odds ratio, OR: 0.07; 95% confidence interval, CI: 0.01 to 0.66; P = 0.02). The prevalence was higher among males (OR: 1.55), and was associated with maternal infection (OR: 1.81), infection of both parents (OR: 1.5), vomiting (OR: 1.28), intestinal parasitosis (OR: 2.25), previous hospitalization (OR: 0.69) and breastfeeding (OR: 1.87). CONCLUSIONS: The prevalence was high among subjects older than three years of age, thus suggesting that the incidence of infection was higher over the first three years of life. Previous use of antibiotics was inversely associated with current Helicobacter pylori infection. (AU)

• FAPESP's process: 10/51098-2 - Natural history and risk factors associated with the incidence of Helicobacter pylori infection in Indian children under 5 years of ethnic Guarani
• Grantee: Elisabete Kawakami
• Support Opportunities: Regular Research Grants