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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

S100A8/MYD88/NF-O > B: a novel pathway involved in cardiomyocyte hypertrophy driven by thyroid hormone

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Cremasco Takano, Ana Paula ; Munhoz, Carolina Demarchi ; Moriscot, Anselmo Sigari ; Gupta, Sudhiranjan ; Morais Barreto-Chaves, Maria Luiza
Total Authors: 5
Document type: Journal article
Source: JOURNAL OF MOLECULAR MEDICINE-JMM; v. 95, n. 6, p. 671-682, JUN 2017.
Web of Science Citations: 4

Recent studies have evidenced the involvement of inflammation-related pathways to the development of cardiac hypertrophy and other consequences on the cardiovascular system, including the calcium-binding protein S100A8. However, this has never been investigated in the thyroid hormone (TH)-prompted cardiac hypertrophy. Thus, we aimed to test whether S100A8 and related signaling molecules, myeloid differentiation factor-88 (MyD88) and nuclear factor kappa B (NF-kappa B), could be associated with the cardiomyocyte hypertrophy induced by TH. Our results demonstrate that the S100A8/MyD88/NF-kappa B signaling pathway is activated in cardiomyocytes following TH stimulation. The knockdown of S100A8 and MyD88 indicates the contribution of those molecules to cardiomyocyte hypertrophy in response to TH, as evaluated by cell surface area, leucine incorporation assay, and gene expression. Furthermore, S100A8 and MyD88 are crucial mediators of NF-kappa B activation, which is also involved in the hypertrophic growth of TH-treated cardiomyocytes. Supporting the in vitro data, the contribution of NF-kappa B for TH-induced cardiac hypertrophy is confirmed in vivo, by using transgenic mice with cardiomyocyte-specific suppression of NF-kappa B. These data identify a novel pathway regulated by TH that mediates cardiomyocyte hypertrophy. However, the potential role of this new pathway in short and long-term cardiac effects of TH remains to be further investigated. (AU)

FAPESP's process: 15/01166-5 - Effect of cardiac specific inhibition of NF-kB in cardiac hypertrophy induced by thyroid hormone
Grantee:Ana Paula Cremasco Takano
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 11/23352-4 - Association between inflammation-related pathways and cardiac hypertrophy induced by thyroid hormone. role of the renin-angiotensin system
Grantee:Ana Paula Cremasco Takano
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/22480-4 - Inflammation and cardiac hypertrophy induced by thyroid hormones: contribution of renin-angiotensin system
Grantee:Maria Luiza de Morais Barreto de Chaves
Support type: Regular Research Grants