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Effect of cardiac specific inhibition of NF-kB in cardiac hypertrophy induced by thyroid hormone

Grant number: 15/01166-5
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): June 01, 2015
Effective date (End): November 30, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Maria Luiza de Morais Barreto de Chaves
Grantee:Ana Paula Cremasco Takano
Supervisor: Sudhiranjan Gupta
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Texas A&M University, United States  
Associated to the scholarship:11/23352-4 - Association between inflammation-related pathways and cardiac hypertrophy induced by thyroid hormone. Role of the Renin-Angiotensin System, BP.DR


Although most of effects of nuclear factor ›kappaB (NF-k›B) is related to inflammatoryresponse, this nuclear factor has been shown to be involved in the development ofcardiac hypertrophy resulted by diverse stimuli. In the present study, we willinvestigate whether the thyroid hormone (TH) action leading to cardiac hypertrophy ismediated by NF-k›B. Transgenic mice that contain specific mutations that preventIk›B phosphorylation and degradation and thereby inhibit NF-›kB activation in cardiactissue as well as wild-type mice will be submitted to hyperthyroidism for 14 days.Morphological and functional parameters correlated to cardiac hypertrophy responsewill be analyzed. These findings will improve understanding of the cardiachypertrophy observed in hyperthyroidism and provide new insights into thegeneration of future therapeutic strategies. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHIASSON, VALORIE; TAKANO, ANA PAULA CREMASCO; GULERIA, RAKESHWAR S.; GUPTA, SUDHIRANJAN. Deficiency of MicroRNA miR-1954 Promotes Cardiac Remodeling and Fibrosis. JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 8, n. 21, . (15/01166-5)
CREMASCO TAKANO, ANA PAULA; MUNHOZ, CAROLINA DEMARCHI; MORISCOT, ANSELMO SIGARI; GUPTA, SUDHIRANJAN; MORAIS BARRETO-CHAVES, MARIA LUIZA. S100A8/MYD88/NF-O > B: a novel pathway involved in cardiomyocyte hypertrophy driven by thyroid hormone. JOURNAL OF MOLECULAR MEDICINE-JMM, v. 95, n. 6, p. 671-682, . (11/23352-4, 15/01166-5, 13/22480-4)

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