Transforming growth factor-, interleukin-17, and IL-23 gene expression profiles associated with human peri-implantitis

Author(s)

Mardegan, Gustavo Pereira ; Shibli, Jamil Awad ; Roth, Leandro Amadeu ; Faveri, Marcelo ; Giro, Gabriela ; Bastos, Marta Ferreira

• Document type: Journal article
• Source: Clinical Oral Implants Research; v. 28, n. 7, p. e10-e15, JUL 2017.
• Web of Science Citations: 4

Abstract

ObjectivesThe mRNA expression profiles of IL-23/Th17 and the Treg-associated cytokine TGF- in peri-implantitis are currently under research. This study characterized the IL-17, IL-23, and TGF- gene expression levels in healthy and diseased peri-implant tissues and correlated these data with radiographic bone loss. Material and MethodsPeri-implant soft tissues from 40 subjects (20 healthy controls with mean age of 59.46.3, and 20 with peri-implantitis with mean age of 56.65.5) were enrolled in this study, and real-time PCR (RT-PCR) was used to define the profile of IL-17, IL-23, and TGF- gene expression. ResultsHigher levels of TGF- mRNA were observed in biopsies taken from healthy controls, and the IL-23 mRNA levels were significantly increased in the peri-implantitis group (P<0.0001). No differences in IL-17 mRNA levels were observed between the two groups (P>0.05). ConclusionsData presented in this report demonstrated a predominant Th17 response in peri-implantitis subjects based on the higher levels of IL-23 and lower levels of TGF- detected. (AU)

• FAPESP's process: 08/07154-5 - Immunological evaluation of surgical treatment of peri-implantitis using Er, Cr:YSGG associated with systemic antibiotics.
• Grantee: Luciana Aparecida de Gouveia Cardoso
• Support Opportunities: Scholarships in Brazil - Master