Modeling for Taxol® Separation in a simulated moving bed

Marco Aurelio Cremasco; Axel Nicolas Starqui

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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Modeling for Taxol® Separation in a simulated moving bed

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Author(s):	Marco Aurelio Cremasco ^[1] ; Axel Nicolas Starqui ^[2] Total Authors: 2
Affiliation:	^[1] Universidade Estadual de Campinas. Faculdade de Engenharia Química - Brasil ^[2] Universidade Estadual de Campinas. Faculdade de Engenharia Química - Brasil Total Affiliations: 2
Document type:	Journal article
Source:	Brazilian Archives of Biology and Technology; v. 53, n. 6, p. 1433-1441, 2010-12-00.
Abstract
This work presents an alternative numerical resolution strategy for a model to describe the dynamic of linear adsorption processes involving multicomponent mixture of taxanes with Taxol® (paclitaxel), a powerful anti-cancer agent, and non-identified impurities, in a Simulated Moving Bed (SMB) system. To solve the model, a hybrid method were used. The liquid concentration inside the particles was found analytically and was related with the liquid bed concentration using Duhamel's theorem. The results from simulation were compared with experimental ones from the literature, showing a good agreement, which demonstrated the applicability of the model and of the hybrid resolution proposed. (AU)

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