| Full text | |
| Author(s): |
Elaine Monteiro Cardoso Lopes
[1]
;
Rosana Cristina Carreira
[2]
;
Débora Gomes Agripino
[3]
;
Luce Maria Brandão Torres
[4]
;
Inês Cordeiro
[5]
;
Vanderlan da Silva Bolzani
[6]
;
Sônia Machado de Campos Dietrich
[7]
;
Maria Claudia Marx Young
[8]
Total Authors: 8
|
| Affiliation: | [1] Instituto de Botânica - Brasil
[2] Instituto de Botânica - Brasil
[3] Instituto de Botânica - Brasil
[4] Instituto de Botânica - Brasil
[5] Instituto de Botânica - Brasil
[6] Universidade Estadual Paulista. Instituto de Química - Brasil
[7] Instituto de Botânica - Brasil
[8] Instituto de Botânica - Brasil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 18, p. 655-660, 2008-12-00. |
| Abstract | |
Crude extracts from 17 plant species collected from an Atlantic Forest region in the State of São Paulo (Brazil) have been screened for antifungal, DNA-damaging and acetylcholinesterase inhibiting activities. Of the 34 extracts obtained from leaves and stems of plants assayed for antifungal activity with Cladosporium sphaerospermum and C. cladosporioides 26.5% were active. However, only the extract of leaves of Cabralea canjerana showed a strong inhibition of both fungi. The DNA-damaging assay with mutant strains of Saccharomyces cerevisiae resulted in 11.7 % of the extracts being active whereas 100% of them showed selectivity for the DNA-repair mechanism of topoisomerase II. Of the 17 species analysed, 12 showed anticholinesterasic activity in TLC assay. However, only extracts from Tetrastylidium grandifolium (stems) and Sloanea guianensis (leaves and stems) inhibited acetylcholinesterase activity more than 50% in quantitative assay. (AU) | |
| FAPESP's process: | 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II |
| Grantee: | Vanderlan da Silva Bolzani |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |