Isolation and characterization of 2-pyridone alkaloids and alloxazines from Beauveria bassiana

Full text
Author(s):	Andrioli, W. J. ; Lopes, A. A. ; Cavalcanti, B. C. ; Pessoa, C. ; Nanayakkara, N. P. D. ; Bastos, J. K. Total Authors: 6
Document type:	Journal article
Source:	NATURAL PRODUCT RESEARCH; v. 31, n. 16, p. 1920-1929, 2017.
Web of Science Citations:	1
Abstract
Two novel compounds bearing heterocyclic nitrogen, 2-pyridone alkaloid (1) and alloxazine derivative (2), along with the known pretenellin B (3), pyridovericin (4) and lumichrome (5) were isolated from a culture of the entomopathogenic fungal strain Beauveria bassiana. The chemical structures of 2-pyridone alkaloid and alloxazine derivative were established on the basis of the interpretation of spectroscopic data. The isolated compounds were evaluated in a panel of five cancer cell lines and pyridovericin exhibited cytotoxicity (IC50, M) against cancer cell lines: HL-60 (25.9 +/- 0.3), HCT8 (34.6 +/- 3.6), MDA-MB435 (34.8 +/- 3.8) and SF295 (31.1 +/- 0.6). Considering that other pyridone compounds display good cytotoxic activity, it would be suggested to obtain new semi synthetic derivatives of pyridovericin, for the development of new cytotoxic chemical entities. {[}GRAPHICS] . (AU)

FAPESP's process:	04/07935-6 - Bioprospection in fungi: the search of lead compounds for drug design and enzymes for pharmaceutical and industrial applications
Grantee:	Jairo Kenupp Bastos
Support Opportunities:	BIOTA-FAPESP Program - Thematic Grants