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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Peptide dendrimers: drug/gene delivery and other approaches

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Author(s):
Santos, S. S. ; Gonzaga, R. V. ; Silva, J. V. ; Savino, D. F. ; Prieto, D. ; Shikay, J. M. ; Silva, R. S. ; Paulo, L. H. A. ; Ferreira, E. I. ; Giarolla, J.
Total Authors: 10
Document type: Review article
Source: Canadian Journal of Chemistry; v. 95, n. 9, p. 907-916, SEP 2017.
Web of Science Citations: 12
Abstract

Dendrimers are versatile hyperbranched molecules, which have deserved attention especially for their potential in many applications, including biological. Peptide dendrimers comprise interesting classes of dendrimers, and their use has been emphasized as a drug/bioactive compound delivery system, mostly in the antineoplastic area. The bioactive molecules can be covalently linked or entrapped inside the peptide derivative. Self-assembled nanocarriers are a recent trend in the design of potential delivery systems, and pH-sensitive carriers, one of their methods, have been designed to control their systems. In addition, the use of targeting peptides or other specific groups that direct the drug/bioactive compounds to specific organs is an important trend in the search for better drug delivery systems. Recent examples have been given in the literature, showing that gene delivery as another important peptide dendrimer application. It is worth emphasizing that some peptide dendrimers show activity per se, without bioactive compounds. Immune compounds and vaccines are presented herein, as well as uses of other peptide dendrimers are briefly discussed in this review, which encompasses around 10 years of work. (AU)

FAPESP's process: 16/11555-1 - Characterization, purification and studies of chemical and enzymatic stability of synthetic intermediates and targeted dendrimer potentially active in Chagas Disease
Grantee:Jennifer Midori Shikay
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/19438-1 - Synthesis and studies of bioactive compounds release from dendrimer prodrugs and targeted drugs potentially active in neglected diseases
Grantee:Jeanine Giarolla Vargas
Support Opportunities: Regular Research Grants