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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biomarkers of fatigue related to adjuvant chemotherapy for breast cancer: evaluation of plasma and lymphocyte expression

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Author(s):
Cruz, Felipe M. ; Munhoz, Bruna A. ; Alves, Beatriz C. A. ; Gehrke, Flavia S. ; Fonseca, Fernando L. A. ; Kuniyoshi, Renata K. ; Cubero, Daniel ; Peppone, Luke J. ; del Giglio, Auro
Total Authors: 9
Document type: Journal article
Source: CLINICAL AND TRANSLATIONAL MEDICINE; v. 4, 2015.
Web of Science Citations: 11
Abstract

Background: Fatigue is common in cancer patients receiving adjuvant chemotherapy. To further understand the mechanism of fatigue and search for potential biomarkers, we conducted this prospective study. Methods We enrolled breast cancer (BC) patients before their first adjuvant Adriamycin-based chemotherapy cycle. Patients responded to the brief fatigue inventory (BFI) and Chalder fatigue questionnaires and had their blood drawn for both plasma evaluation and evaluation of the peripheral mononuclear cell fraction (PMNCF) mRNA expression of various biomarkers. We evaluated FSH, LH, estradiol, DHEA, DHEAS, IL6, IL2, ILIRA, IL1 beta, CRP, Cortisol in the plasma and IL2, IL10, IL6, TGF-beta, KLRC1, TNF, BTP, SNCA, SOD1, BLNK, PTGS2 and INF gamma expression in the PMNCF. Results: 11 patients did not exhibit an increase in their BFI scores and served as controls, whereas 32 patients exhibited an increase in their BFI scores compared with the baseline scores. From the biomarkers we evaluated in the PMNCF, the only one significantly associated with fatigue was TGF-beta (p = 0.0343), while there was a trend towards significance with KLRC1 (p = 0.0627). We observed no evidence of significant associations of any plasma biomarkers with the development of fatigue. However when we analyzed patients with more severe fatigue, plasma IL1-RA levels correlated directly with higher fatigue scores (p = 0.0136). Conclusions: We conclude that fatigue induced by chemotherapy in BC patients is associated with changes in IL1-ra plasma levels and in TGF-beta lymphocyte expression. Its mechanism may be different than that observed in long-term BC survivors or that induced by radiation therapy. (AU)

FAPESP's process: 10/52036-0 - Biomarkers of fatigue induced by chemotherapy for breast cancer during guarana (Paullinia cupana) treatment
Grantee:Auro del Giglio
Support Opportunities: Regular Research Grants