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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Feulgen reaction: A brief review and new perspectives

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Author(s):
Mello, Maria Luiza S. ; Vidal, Benedicto de Campos
Total Authors: 2
Document type: Review article
Source: ACTA HISTOCHEMICA; v. 119, n. 6, p. 603-609, 2017.
Web of Science Citations: 5
Abstract

The Feulgen reaction has been proposed by Robert Feulgen and Heinrich Rossenbeck for the identification of DNA nearly a hundred years ago. Since then, many other applications of this cytochemical/topochemical procedure at qualitative and quantitative level have been proposed in relation to DNA and its role in chromatin in human, animal and plant cells. In this article, we briefly review some fundamental aspects of the Feulgen reaction and current applications of such a method in studies of altered chromatin texture, including its association with or preceding changes in transcriptional activities and effect on epigenetic marks. Further perspectives on the use of the Feulgen reaction will depend of the proposal of innovative biological questions in which its reveals appropriate. (AU)

FAPESP's process: 15/10356-2 - Action of valproic acid on chromatin structure and function
Grantee:Maria Luiza Silveira Mello
Support Opportunities: Research Projects - Thematic Grants