| Full text | |
| Author(s): |
Gomes, Tarcisio Santana
;
Aoike, Danilo Takashi
;
Baria, Flavia
;
Graciolli, Fabiana G.
;
Moyses, Rosa M. A.
;
Cuppari, Lilian
Total Authors: 6
|
| Document type: | Journal article |
| Source: | JOURNAL OF RENAL NUTRITION; v. 27, n. 5, p. 364-371, SEP 2017. |
| Web of Science Citations: | 4 |
| Abstract | |
Objective: The aim of the study was to investigate the effect of aerobic exercise on markers of bone metabolism in overweight and obese nondialysis-dependent patients with chronic kidney disease. Methods: This is a post-hoc study with 39 sedentary patients (55.5 +/- 68.3 years, body mass index 31.2 +/- 64.4 kg/m(2), estimated glomerular filtration rate 26.9 +/- 6 11.7 mL/minute) who were randomly assigned to the aerobic exercise group (n = 24) or the control group (n = 15). The aerobic training (walking) was prescribed according to ventilatory threshold and was performed 3 times per week during 24 weeks. Carboxylated and undercarboxylated osteocalcin (GLA and GLU), sclerostin and tartrate-resistant acid phosphatase isoform 5b (TRAP-5b), parathyroid hormone, total alkaline phosphatase (AP), body composition, cardiorespiratory, and functional capacity tests were measured at baseline and after the follow-up. Results: At baseline, carboxylated osteocalcin (GLA) and undercarboxylated osteocalcin (GLU) were inversely correlated with estimated glomerular filtration rate (r = -0.64; r = -0.38, respectively). Both osteocalcin fragments were positively correlated with total AP (GLA: r = 0.36; GLU: r = 0.53). An inverse correlation was found between GLA and sclerostin with body fat (r = -0.36; r = -0.46, respectively). GLU was negatively correlated with markers of muscle mass (r = -0.34). TRAP-5b and sclerostin were inversely correlated with 6-minute walk test and time up and go test, respectively (r = -0.34; r = -0.35, respectively). After 24 weeks, all physical capacity parameters increased in the exercise group (P < .001). Except for total AP that increased after 24 weeks in the exercise group (P < 05), no other changes were observed in both groups in relation to the bone metabolism biomarkers investigated. Conclusion(s): In this post-hoc study, the aerobic training used did not promote relevant changes in the bone metabolism markers investigated. (C) 2017 by the National Kidney Foundation, Inc. All rights reserved. (AU) | |
| FAPESP's process: | 09/14786-0 - Effects of a home-based aerobic training program in relation to a supervised training on physical functioning, nutritional and cardiometabolic parameters in overweight or obese chronic kidney disease patients. |
| Grantee: | Lilian Cuppari |
| Support Opportunities: | Regular Research Grants |