Effects of exposure to biomass burning on pulmonary inflammatory markers and pulmonary function in individuals with COPD

Author(s)

Ramos, D. ^[1] ; Proenca, M. ^[2] ; Leite, M. R. ^[3] ; Ferreira, A. D. ^{[1, 4]} ; Trevisan, I. B. ^[1] ; Brigida, G. F. S. ^[1] ; Tacao, G. Y. ^[1] ; Ramos, E. M. C. ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Physiotherapy, Presidente Prudente, SP - Brazil

^[2] State Univ North Parana UENP, Dept Physiotherapy, Jacarezinho, Parana - Brazil

^[3] Univ Sao Paulo, Med Sch, Heart Inst, Pulm Div, Sao Paulo - Brazil

^[4] Univ Western Sao Paulo, Dept Physiotherapy, Presidente Prudente, SP - Brazil

• Document type: Journal article
• Source: Revista Portuguesa de Pneumologia; v. 23, n. 5, p. 273-279, SEP-OCT 2017.
• Web of Science Citations: 2

Abstract

Introduction: Pulmonary rehabilitation (PR) has many benefits for individuals with COPD. How ever, it is not clear whether PR could prevent the hazards of air pollution exposure. This study aimed to analyze the effects of biomass burning exposure on pulmonary inflammatory markers and pulmonary function in individuals with COPD, participants and non-participants of PR. Methods: 35 subjects were divided into three groups: individuals with COPD who received PR (G1, n=15), those who did not (G2, n=10), and a control group composed of healthy individuals without COPD (CG, n=10). Measurements of lung function and concentrations of IL-6, IL-10, and TNF-alpha in exhaled breath condensate samples were collected. The assessment and concentrations of particulate matter (PM10), nitrogen dioxide (NO2), ozone (O-3), temperature (T), and relative air humidity (RAH) were recorded in biomass burning and non-burning periods. Results: There was a significant increase in the concentrations of air pollutants in the biomass burning period. In this period, an increase in IL-6 (G1p = 0.041, G2 p = .012), and a reduction in the FEV1/FVC ratio (G1p = 0.021, G2 p = .007) were observed in individuals with COPD. In G1, the increase in IL-6 concentrations correlated positively with O-3 (r = 0.693; p = .006), and negatively with RAH (r = -0.773; p = .003) in the burning period. Conclusions: Individuals with COPD exposed to biomass burning demonstrated increased pulmonary inflammation and a reduction in the FEV1/FVC ratio, regardless of their engagement in PR. (C) 2017 Published by Elsevier Espana, S.L.U. (AU)

• FAPESP's process: 12/12901-0 - Air pollution in COPD: analysis of inflammatory markers, mucociliary transportability and quality of life
• Grantee: Dionei Ramos
• Support Opportunities: Regular Research Grants