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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determining the Roles of Inositol Trisphosphate Receptors in Neurodegeneration: Interdisciplinary Perspectives on a Complex Topic

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Takada, Silvia Honda [1] ; Ikebara, Juliane Midori [1] ; de Sousa, Erica [1] ; Cardoso, Debora Sterzeck [1] ; Resende, Rodrigo Ribeiro [2] ; Ulrich, Henning [3] ; Rueckl, Martin [4] ; Ruediger, Sten [4] ; Kihara, Alexandre Hiroaki [5, 1]
Total Authors: 9
[1] Univ Fed ABC, Lab Neurogenet, Sao Bernardo Do Campo, SP - Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Cell Signaling & Nanobiotechnol Lab, Dept Biochem & Immunol, Belo Horizonte, MG - Brazil
[3] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, SP - Brazil
[4] Humboldt Univ, Inst Phys, Berlin - Germany
[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Molecular Neurobiology; v. 54, n. 9, p. 6870-6884, NOV 2017.
Web of Science Citations: 1

It is well known that calcium (Ca2+) is involved in the triggering of neuronal death. Ca2+ cytosolic levels are regulated by Ca2+ release from internal stores located in organelles, such as the endoplasmic reticulum. Indeed, Ca2+ transit from distinct cell compartments follows complex dynamics that are mediated by specific receptors, notably inositol trisphosphate receptors (IP3Rs). Ca2+ release by IP3Rs plays essential roles in several neurological disorders; however, details of these processes are poorly understood. Moreover, recent studies have shown that subcellular location, molecular identity, and density of IP3Rs profoundly affect Ca2+ transit in neurons. Therefore, regulation of IP3R gene products in specific cellular vicinities seems to be crucial in a wide range of cellular processes from neuroprotection to neurodegeneration. In this regard, microRNAs seem to govern not only IP3Rs translation levels but also subcellular accumulation. Combining new data from molecular cell biology with mathematical modelling, we were able to summarize the state of the art on this topic. In addition to presenting how Ca2+ dynamics mediated by IP3R activation follow a stochastic regimen, we integrated a theoretical approach in an easy-to-apply, cell biology-coherent fashion. Following the presented premises and in contrast to previously tested hypotheses, Ca2+ released by IP3Rs may play different roles in specific neurological diseases, including Alzheimer's disease and Parkinson's disease. (AU)

FAPESP's process: 11/50151-0 - Dynamical phenomena in complex networks: fundamentals and applications
Grantee:Elbert Einstein Nehrer Macau
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/16711-6 - MicroRNAs and cell coupling interplay in the development, adaptation and degeneration of the nervous system
Grantee:Alexandre Hiroaki Kihara
Support type: Regular Research Grants
FAPESP's process: 12/50880-4 - Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications
Grantee:Alexander Henning Ulrich
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/50122-0 - Dynamic phenomena in complex networks: basics and applications
Grantee:Elbert Einstein Nehrer Macau
Support type: Research Projects - Thematic Grants