Advanced search
Start date
Betweenand

Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications

Grant number: 12/50880-4
Support type:Research Projects - Thematic Grants
Duration: December 01, 2012 - February 28, 2019
Field of knowledge:Biological Sciences - Biophysics - Cellular Biophysics
Principal Investigator:Alexander Henning Ulrich
Grantee:Alexander Henning Ulrich
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:LUIZ ROBERTO GIORGETTI DE BRITTO ; Marimélia Aparecida Porcionatto
Associated scholarship(s):18/03607-7 - Culture and differentiation of dopaminergic neurons from embryonic stem cells, BP.TT
18/05543-6 - GABAergic neurons differentiation from mouse embryonic stem cells, BP.TT
17/17972-6 - Silencing of CaMKII-alpha in a hippocampal cell line as an in vitro model for the immature dentate gyrus neuropsychiatric endophenotype, BP.IC
+ associated scholarships 15/15826-7 - Collagen hydrogel modified by bi-functional recombinant protein for transplantation of neural stem cells for the treatment of neurodegenerative disorder, BP.PD
15/14343-2 - Dental pulp derived mesenchymal stem cells and its conditioned medium: a novel therapeutic approach for ALS, BP.PD
15/18730-0 - Lung cancer stem cells by DNA aptamers identification / purification and kallikrein-kinin system study on tumor progression, BP.PD
15/14342-6 - Identification of aptamers binding to human glioblastoma cells, BP.IC
14/26637-8 - Enrichment of cancer stem-like cells in glioblastoma multiforme, BP.IC
14/00462-7 - Identification of DNA aptamers to human glioblastoma stem-like cells, BP.DR
13/12786-9 - Participation of bradykinin in adult mouse neurogenesis, BP.MS
13/06044-0 - Parkinson disease: possible involvement of kinin, purinergic and transient potential receptors., BP.DR
13/02293-5 - Aptamers inhibiting the protein CD73 as possible antitumoral agents, BP.PD
12/24205-8 - Investigation on the role of P2X4 purinergic receptor during neuronal differentiation of P19 cells through interference RNA, BP.IC - associated scholarships

Abstract

Stem cells (SC) are unspecialized cells withself renewal capacity and with the ability to originate different cell types | of the body. In recent years, SC nave emerged as a significant therapeutic promise for several diseases. Furthermore, cancer stem cells (CSC ) have been implicated in initiation and growth of tumors, resistance to conventional therapies and, consequently, in recurrence of the disease, becoming a potential target for therapy. The basic structure of a SC depends on its genetic constitution, however the determination of a specific phenotype also depends on cell exposure to intrinsic and extrinsic factors in their microenvironment. Our laboratory has been studying the role of bradykinin (BK) and purines in induction, progression and phenotype determination in neural differentiation of different types of SC. As one of the main findings of our group, BK increased neurogenesis in several models of SC and also showed a neuroprotective effect, reversing the induction of apoptosis. Based on these data, in this project, we propose to study the interrelationship between purinergic and kininergic systems as a target for therapies using SC. For this purpose, we will evaluate the effect of BK and its stable analogs as potential tools for cell therapy in a preclinical model of Parkinson's disease, together with neural stem cell transplantation. Somatic cells of Parkinson's disease patients will be reprogrammed to pluripotent cells (iPS) to study possible alterations in the kininergic and purinergic systems and in their effects on the modulation of neural differentiation. We will develop DNA aptamers in order to obtain specific markers for different types of SC, such as mesenchymal and cancer SC. These aptamers have possible therapeutic applications, in the purification of mesenchymal SC for cell therapy and, in the case of tumor SC, have a diagnostic value in detection of those cells in biological fluids. To define new therapeutic targets and regarding the anti-proliferative effect of BK on neural stem cells (NSC), we will study the expression of kinin system and the involvement of their receptors on tumor progression in cells derived from lung tumors and glioblastoma with high malignancy. Furthermore, we will study P2X7 receptor in a mouse model of epilepsy, providing a second pre-clinical model in addition to the rat model for Parkinson's disease. (AU)

Scientific publications (62)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TROMBETTA-LIMA, MARINA; ASSIS-RIBAS, THAIS; CINTRA, RICARDO C.; CAMPEIRO, JOANA D.; GUERREIRO, JULIANO R.; WINNISCHOFER, SHEILA M. B.; NASCIMENTO, ISIS C. C.; ULRICH, HENNING; HAYASHI, MIRIAN A. F.; SOGAYAR, MARI C. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. MOLECULAR BIOLOGY REPORTS, v. 48, n. 2 FEB 2021. Web of Science Citations: 0.
ZAPARTE, ALINE; CAPPELLARI, ANGELICA R.; BRANDAO, CAROLINE A.; DE SOUZA, JULIA B.; BORGES, THIAGO J.; KIST, LUIZA W.; BOGO, MAURICIO R.; ZERBINI, LUIZ F.; RIBEIRO PINTO, LUIS FELIPE; GLASER, TALITA; GONCALVES, MARIA CAROLINA B.; NAALDIJK, YAHAIRA; ULRICH, HENNING; MORRONE, FERNANDA B. P2Y(2) receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway. European Journal of Pharmacology, v. 891, JAN 15 2021. Web of Science Citations: 0.
PILLAT, MICHELI MAINARDI; OLIVEIRA-GIACOMELLI, AGATHA; DAS NEVES OLIVEIRA, MONA; ANDREJEW, ROBERTA; TURRINI, NATALIA; BARANOVA, JULIANA; LAH TURNSEK, TAMARA; ULRICH, HENNING. Mesenchymal stem cell-glioblastoma interactions mediated via kinin receptors unveiled by cytometry. Cytometry Part A, v. 99, n. 2, SI JAN 2021. Web of Science Citations: 0.
RAJPUROHIT, CHETAN SINGH; KUMAR, VIVEK; CHEFFER, ARQUIMEDES; OLIVEIRA, DANYLLO; ULRICH, HENNING; OKAMOTO, OSWALDO KEITH; ZATZ, MAYANA; ANSARI, UZAIR AHMAD; KHANNA, VINAY KUMAR; PANT, ADITYA BHUSHAN. Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1(L39R)Linked Amyotrophic Lateral Sclerosis. Molecular Neurobiology, JUL 2020. Web of Science Citations: 0.
HIRSCH, MAURO MOZAEL; DECKMANN, IOHANNA; SANTOS-TERRA, JULIO; STAEVIE, GABRIELA ZANOTTO; FONTES-DUTRA, MELLANIE; CARELLO-COLLAR, GIOVANNA; KORBES-ROCKENBACH, MARILIA; SCHWINGEL, GUSTAVO BRUM; BAUER-NEGRINI, GUILHERME; RABELO, BRUNA; BITTENCOURT GONCALVES, MARIA CAROLINA; CORREA-VELLOSO, JULIANA; NAALDIJK, YAHAIRA; GECIAUSKAS CASTILLO, ANA REGINA; SCHNEIDER, TOMASZ; BAMBINI-JUNIOR, VICTORIO; ULRICH, HENNING; GOTTFRIED, CARMEM. Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism. Neuropharmacology, v. 167, MAY 1 2020. Web of Science Citations: 0.
GLASER, TALITA; SHIMOJO, HIROMI; RIBEIRO, DEIDIANE ELISA; MARTINS, PATRICIA PEREIRA LOPES; BECO, RENATA PEREIRA; KOSINSKI, MICHAL; SAMPAIO, VANESSA FERNANDES ARNAUD; CORREA-VELLOSO, JULIANA; OLIVEIRA-GIACOMELLI, AGATHA; LAMEU, CLAUDIANA; DE JESUS SANTOS, ANA PAULA; DE SOUZA, HELLIO DANNY NOBREGA; TENG, YANG D.; KAGEYAMA, RYOICHIRO; ULRICH, HENNING. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. MOLECULAR PSYCHIATRY, APR 2020. Web of Science Citations: 0.
VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; ULRICH, HENNING; AMARAL, ANTONIA T-DO. Virtual Screening Approach for the Identification of Hydroxamic Acids as Novel Human Ecto-5 `-Nucleotidase Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 60, n. 2, p. 621-630, FEB 2020. Web of Science Citations: 1.
BALDISSARELLI, JUCIMARA; MANICA, ALINE; PILLAT, MICHELI MAINARDI; BAGATINI, MARGARETE DULCE; ROSA LEAL, DANIELA BITENCOURT; ABDALLA, FATIMA HUSEIN; MORSCH, VERA M.; ULRICH, HENNING; BORNEMANN, CLARISSA PEREIRA; CHITOLINA SCHETINGER, MARIA R. Increased cytokines production and oxidative stress are related with purinergic signaling and cell survival in post-thyroidectomy hypothyroidism. Molecular and Cellular Endocrinology, v. 499, JAN 1 2020. Web of Science Citations: 0.
NERY, ARTHUR A.; PEREIRA, RICARDO L.; BASSANEZE, VINICIUS; NASCIMENTO, ISIS C.; SHERMAN, LAUREN S.; RAMESHWAR, PRANELA; LAMEU, CLAUDIANA; ULRICH, HENNING. Combination of Chemical and Neurotrophin Stimulation Modulates Neurotransmitter Receptor Expression and Activity in Transdifferentiating Human Adipose Stromal Cells. STEM CELL REVIEWS AND REPORTS, v. 15, n. 6, p. 851-863, DEC 2019. Web of Science Citations: 1.
OLIVEIRA-GIACOMELLI, AGATHA; ALBINO, CAROLINA M.; NOBREGA DE SOUZA, HELLIO DANNY; CORREA-VELLOSO, JULIANA; DE JESUS SANTOS, ANA PAULA; BARANOVA, JULIANA; ULRICH, HENNING. P2Y6 and P2X7 Receptor Antagonism Exerts Neuroprotective/ Neuroregenerative Effects in an Animal Model of Parkinson's Disease. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 13, NOV 8 2019. Web of Science Citations: 0.
FRACASSO, MATEUS; PILLAT, MICHELI M.; BOTTARI, NATHIELI B.; DA SILVA, ANIELEN D.; GRANDO, THIRSSA H.; MATOS, ANTONIO F. I. M.; PETRY, LETICIA S.; ULRICH, HENNING; DE ANDRADE, CINTHIA M.; MONTEIRO, SILVIA G.; DA SILVA, ALEKSANDRO S. Trypanosoma evansi impacts on embryonic neural progenitor cell functions. Microbial Pathogenesis, v. 136, NOV 2019. Web of Science Citations: 0.
GLASER, TALITA; ARNAUD SAMPAIO, VANESSA FERNANDES; LAMEU, CLAUDIANA; ULRICH, HENNING. Calcium signalling: A common target in neurological disorders and neurogenesis. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 95, n. SI, p. 25-33, NOV 2019. Web of Science Citations: 4.
LINZKE, MARLEEN; YAN, SUN LIU REI; TARNOK, ATTILA; ULRICH, HENNING; GROVES, MATTHEW R.; WRENGER, CARSTEN. Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum. Cytometry Part A, v. 97, n. 7, SI NOV 2019. Web of Science Citations: 1.
REICHERT, KARINE P.; SCHETINGER, MARIA ROSA C.; PILLAT, MICHELI M.; BOTTARI, NATHIELI B.; PALMA, TAIS V.; GUTIERRES, JESSIE M.; ULRICH, HENNING; ANDRADE, CINTHIA M.; EXLEY, CHRISTOPHER; MORSCH, VERA M. M. Aluminum affects neural phenotype determination of embryonic neural progenitor cells. ARCHIVES OF TOXICOLOGY, v. 93, n. 9, p. 2515-2524, SEP 2019. Web of Science Citations: 1.
RIBEIRO, D. E.; GLASER, T.; OLIVEIRA-GIACOMELLI, A.; ULRICH, H. Purinergic receptors in neurogenic processes. Brain Research Bulletin, v. 151, n. SI, p. 3-11, SEP 2019. Web of Science Citations: 1.
FRACASSO, MATEUS; BOTTARI, NATHIELI B.; DA SILVA, ANIELEN D.; GRANDO, THIRSSA H.; PILLAT, MICHELI M.; ULRICH, HENNING; VIDAL, TAIS; DE ANDRADE, CINTHIA M.; MONTEIRO, SILVIA G.; NASCIMENTO, LUIZ FLAVIO N.; MILETTI, LUIZ CLAUDIO; DA SILVA, ALEKSANDRO SCHAFER. Effects of resveratrol on the differentiation fate of neural progenitor cells of mouse embryos infected with Trypanosoma cruzi. Microbial Pathogenesis, v. 132, p. 156-161, JUL 2019. Web of Science Citations: 1.
RIBEIRO, DEIDIANE ELISA; RONCALHO, ALINE LULHO; GLASER, TALITA; ULRICH, HENNING; WEGENER, GREGERS; JOCA, SAMIA. P2X7 Receptor Signaling in Stress and Depression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11 JUN 1 2019. Web of Science Citations: 0.
BAGATINI, MARGARETE DULCE; BERTOLIN, KALYNE; BRIDI, ALESSANDRA; PELINSON, LUANA PAULA; ROSA BONADIMAN, BEATRIZ DA SILVA; PILLAT, MICHELE MAINARDI; DIAS GONCALVES, PAULO BAYARD; ULRICH, HENNING; CHITOLINA SCHETINGER, MARIA ROSA; MORSCH, VERA MARIA. 1, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells. Journal of Cellular Biochemistry, v. 120, n. 6, p. 9992-10000, JUN 2019. Web of Science Citations: 0.
DA SILVA, ARUA C.; HIGGINS, MICHAEL J.; CORDOBA DE TORRESI, SUSANA I. The effect of nanoscale surface electrical properties of partially biodegradable PEDOT-co-PDLLA conducting polymers on protein adhesion investigated by atomic force microscopy. Materials Science & Engineering C-Materials for Biological Applications, v. 99, p. 468-478, JUN 2019. Web of Science Citations: 2.
BOTTARI, NATHIELI B.; SCHETINGER, MARIA ROSA C.; PILLAT, MICHELI M.; PALMA, THAIS V.; ULRICH, HENNING; ALVES, MARIANA S.; MORSCH, VERA M.; MELAZZO, CINTHIA; DE BARROS, LUIZ DANIEL; GARCIA, JOAO LUIS; DA SILVA, ALEKSANDRO SCHAFER. Resveratrol as a Therapy to Restore Neurogliogenesis of Neural Progenitor Cells Infected by Toxoplasma gondii. Molecular Neurobiology, v. 56, n. 4, p. 2328-2338, APR 2019. Web of Science Citations: 3.
BOTTARI, NATHIELI B.; PILLAT, MICHELI M.; SCHETINGER, MARIA R. C.; REICHERT, KARINE P.; MACHADO, VANESSA; ASSMANN, CHARLES E.; ULRICH, HENNING; DUTRA, ANIELEN; MORSCH, VERA M.; VIDAL, TAIS; DA CRUZ, IVANA B. M.; MELAZZO, CINTHIA; DA SILVA, ALEKSANDRO SCHAFER. Resveratrol-mediated reversal of changes in purinergic signaling and immune response induced by Toxoplasma gondii infection of neural progenitor cells. PURINERGIC SIGNALLING, v. 15, n. 1, p. 77-84, MAR 2019. Web of Science Citations: 1.
ALVES, JANAINA M.; MARTINS, ANTONIO H.; LAMEU, CLAUDIANA; GLASER, TALITA; BOUKLI, NAWAL M.; BASSANEZE, VINICIUS; DARIOLLI, RAFAEL; NASCIMENTO, ISIS C.; MARTINS, POLIANA C. M.; DE SOUZA, HELLIO D. N.; KRIEGER, JOSE EDUARDO; CASARINI, DULCE E.; SALES, VICENCIA M.; PESQUERO, JOAO B.; ULRICH, HENNING. Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation. STEM CELL REVIEWS AND REPORTS, v. 15, n. 1, p. 48-58, FEB 2019. Web of Science Citations: 1.
PINTO FILHO, SAULO T. L.; PILLAT, MICHELI M.; ROSA, MATHEUS P.; DALMOLIN, FABIOLA; ULRICH, HENNING; PIPPI, NEY L. Expression patterns of mesenchymal stem cell-specific proteins in adipose tissue-derived cells: possible immunosuppressing agent in partial allograft for restoring the urinary bladder in rabbits. Pesquisa Veterinária Brasileira, v. 38, n. 12, p. 2183-2189, DEC 2018. Web of Science Citations: 0.
VIEIRA, JULIANO MARCHI; GUTIERRES, JESSIE MARTINS; CARVALHO, FABIANO BARBOSA; STEFANELLO, NAIARA; OLIVEIRA, LIZIELLE; CARDOSO, ANDREIA MACHADO; MORSCH, VERA MARIA; PILLAT, MICHELI MAINARDI; ULRICH, HENNING; FRESCURA DUARTE, MARTA MEDEIROS; CHITOLINA SCHETINGER, MARIA ROSA; SPANEVELLO, ROSELIA MARIA. Caffeine and high intensity exercise: Impact on purinergic and cholinergic signalling in lymphocytes and on cytokine levels. BIOMEDICINE & PHARMACOTHERAPY, v. 108, p. 1731-1738, DEC 2018. Web of Science Citations: 1.
VIEIRA, MARIANA S.; SANTOS, ANDERSON K.; VASCONCELLOS, REBECCA; GOULART, VANIA A. M.; PARREIRA, RICARDO C.; KIHARA, ALEXANDRE H.; ULRICH, HENNING; RESENDE, RODRIGO R. Neural stem cell differentiation into mature neurons: Mechanisms of regulation and biotechnological applications. BIOTECHNOLOGY ADVANCES, v. 36, n. 7, p. 1946-1970, NOV 15 2018. Web of Science Citations: 9.
DE ALMEIDA-PEREIRA, LUANA; REPOSSI, MARINNA GARCIA; MAGALHAES, CAMILA FEITOSA; AZEVEDO, RAFAEL DE FREITAS; CORREA-VELLOSO, JULIANA DA CRUZ; ULRICH, HENNING; MARQUES VENTURA, ANA LUCIA; FRAGEL-MADEIRA, LUCIANNE. P2Y(12) but not P2Y(13) Purinergic Receptor Controls Postnatal Rat Retinogenesis In Vivo. Molecular Neurobiology, v. 55, n. 11, p. 8612-8624, NOV 2018. Web of Science Citations: 2.
TENG, YANG D.; WANG, LEI; KABATAS, SERDAR; ULRICH, HENNING; ZAFONTE, ROSS D. Cancer Stem Cells or Tumor Survival Cells?. STEM CELLS AND DEVELOPMENT, v. 27, n. 21 SEP 25 2018. Web of Science Citations: 7.
ADAMIAK, MATEUSZ; BUJKO, KAMILA; CYMER, MONIKA; PLONKA, MONIKA; GLASER, TALITA; KUCIA, MAGDA; RATAJCZAK, JANINA; ULRICH, HENNING; ABDEL-LATIF, AHMED; RATAJCZAK, MARIUSZ Z. Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells. LEUKEMIA, v. 32, n. 9, p. 1920-1931, SEP 2018. Web of Science Citations: 10.
FRANCA, RAQUELI TERESINHA; PILLAT, MICHELI MAINARDI; DA SILVA, CASSIA BAGOLIN; SCHAFER, ANDRESSA SALVADORI; DORNELLES, GUILHERME LOPES; COSTA, MARCIO MACHADO; CHAVES, RAFAEL OLIVEIRA; DE ANDRADE, CINTHIA MELAZZO; ERHARDT, MAGNOLIA MARTINS; ANTOZIAZZI, ALFREDO QUITES; ULRICH, HENNING; DA SILVA, ALEKSANDRO SCHAFER; DOS ANJOS LOPES, SONIA TEREZINHA. Surface immunoglobulins of erythrocytes and platelets in dogs naturally infected by Rangelia vitalii. Microbial Pathogenesis, v. 121, p. 245-251, AUG 2018. Web of Science Citations: 0.
VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; CHEFFER, ARQUIMEDES; DE REZENDE, LEANDRO; ULRICH, HENNING; CARMONA-RIBEIRO, ANA MARIA; T-DO AMARAL, ANTONIA. Be Aware of Aggregators in the Search for Potential Human ecto-5 `-Nucleotidase Inhibitors. Molecules, v. 23, n. 8 AUG 2018. Web of Science Citations: 3.
VIDIC, MATEJA; SMUC, TINA; JANEZ, NIKA; BLANK, MICHAEL; ACCETTO, TOMAZ; MAVRI, JAN; NASCIMENTO, ISIS C.; NERY, ARTHUR A.; ULRICH, HENNING; LAH, TAMARA T. In silico selection approach to develop DNA aptamers for a stem-like cell subpopulation of non-small lung cancer adenocarcinoma cell line A549. RADIOLOGY AND ONCOLOGY, v. 52, n. 2, p. 152-159, JUN 2018. Web of Science Citations: 1.
ULRICH, HENNING; RATAJCZAK, MARIUSZ Z.; SCHNEIDER, GABRIELA; ADINOLFI, ELENA; ORIOLI, ELISA; FERRAZOLI, ENEAS G.; GLASER, TALITA; CORREA-VELLOSO, JULIANA; MARTINS, POLIANA C. M.; COUTINHO, FERNANDA; SANTOS, ANA P. J.; PILLAT, MICHELI M.; SACK, ULRICH; LAMEU, CLAUDIANA. Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis. FRONTIERS IN PHARMACOLOGY, v. 9, MAY 18 2018. Web of Science Citations: 4.
DA SILVA, ARUA C.; SEMEANO, ANA TERESA S.; DOURADO, ANDRE H. B.; ULRICH, HENNING; CORDOBA DE TORRESI, I, SUSANA. Novel Conducting and Biodegradable Copolymers with Noncytotoxic Properties toward Embryonic Stem Cells. ACS OMEGA, v. 3, n. 5, p. 5593-5604, MAY 2018. Web of Science Citations: 5.
OLIVEIRA-GIACOMELLI, AGATHA; NAALDIJK, YAHAIRA; SARDA-ARROYO, LAURA; GONCALVES, MARIA C. B.; CORREA-VELLOSO, JULIANA; PILLAT, MICHELI M.; DE SOUZA, HELLIO D. N.; ULRICH, HENNING. Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy. FRONTIERS IN PHARMACOLOGY, v. 9, APR 10 2018. Web of Science Citations: 4.
OLIVEIRA, MONA N.; PILLAT, MICHELI M.; MOTALN, HELENA; ULRICH, HENNING; LAH, TAMARA T. Kinin-B1 Receptor Stimulation Promotes Invasion and is Involved in Cell-Cell Interaction of Co-Cultured Glioblastoma and Mesenchymal Stem Cells. SCIENTIFIC REPORTS, v. 8, JAN 22 2018. Web of Science Citations: 4.
CORREA-VELLOSO, JULIANA C.; GONCALVES, MARIA C. B.; NAALDIJK, YAHAIRA; OLIVEIRA-GIACOMELLI, AGATHA; PILLAT, MICHELI M.; ULRICH, HENNING. Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 80, n. A, p. 34-53, JAN 3 2018. Web of Science Citations: 9.
LIANG, NICHOLAS; TRUJILLO, CLEBER A.; NEGRAES, PRISCILLA D.; MUOTRI, ALYSSON R.; LAMEU, CLAUDIANA; ULRICH, HENNING. Stem cell contributions to neurological disease modeling and personalized medicine. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 80, n. A, p. 54-62, JAN 3 2018. Web of Science Citations: 3.
CHEFFER, A.; CASTILLO, A. R. G.; CORREA-VELLOSO, J.; GONCALVES, M. C. B.; NAALDIJK, Y.; NASCIMENTO, I. C.; BURNSTOCK, G.; ULRICH, H. Purinergic system in psychiatric diseases. MOLECULAR PSYCHIATRY, v. 23, n. 1, p. 94-106, JAN 2018. Web of Science Citations: 21.
BALDISSARELLI, JUCIMARA; PILLAT, MICHELI M.; SCHMATZ, ROBERTA; CARDOSO, ANDREIA M.; ABDALLA, FATIMA H.; DE OLIVEIRA, JULIANA S.; POLACHINI, CARLA R. N.; CASALI, EMERSON; BORNEMANN, CLARISSA PEREIRA; ULRICH, HENNING; MORSCH, VERA M.; SCHETINGER, MARIA R. C. Post-thyroidectomy hypothyroidism increases the expression and activity of ectonucleotidases in platelets: Possible involvement of reactive oxygen species. PLATELETS, v. 29, n. 8, p. 801-810, 2018. Web of Science Citations: 3.
MARTINEZ-RAMIREZ, A. S.; DIAZ-MUNOZ, M.; BATTASTINI, A. M.; CAMPOS-CONTRERAS, A.; OLVERA, A.; BERGAMIN, L.; GLASER, T.; MORITZ, C. E. JACINTHO; ULRICH, H.; VAZQUEZ-CUEVAS, F. G. Cellular Migration Ability Is Modulated by Extracellular Purines in Ovarian Carcinoma SKOV-3 Cells. Journal of Cellular Biochemistry, v. 118, n. 12, p. 4468-4478, DEC 2017. Web of Science Citations: 1.
TAKADA, SILVIA HONDA; IKEBARA, JULIANE MIDORI; DE SOUSA, ERICA; CARDOSO, DEBORA STERZECK; RESENDE, RODRIGO RIBEIRO; ULRICH, HENNING; RUECKL, MARTIN; RUEDIGER, STEN; KIHARA, ALEXANDRE HIROAKI. Determining the Roles of Inositol Trisphosphate Receptors in Neurodegeneration: Interdisciplinary Perspectives on a Complex Topic. Molecular Neurobiology, v. 54, n. 9, p. 6870-6884, NOV 2017. Web of Science Citations: 2.
BERGAMIN, LETICIA SCUSSEL; FIGUEIRO, FABRICIO; DIETRICH, FABRICIA; MANICA, FABIANA DE MATTOS; FILIPPI-CHIELA, EDUARDO C.; MENDES, FRANCIANE BRACKMAN; FARIAS JANDREY, ELISA HELENA; LOPES, DANIELA VASCONCELOS; OLIVEIRA, FRANCINE H.; NASCIMENTO, ISIS C.; ULRICH, HENNING; OLIVEIRA BATTASTINI, ANA MARIA. Interference of ursolic acid treatment with glioma growth: An in vitro and in vivo study. European Journal of Pharmacology, v. 811, p. 268-275, SEP 15 2017. Web of Science Citations: 2.
DATI, L. M.; ULRICH, H.; REAL, C. C.; FENG, Z. P.; SUN, H. S.; BRITTO, L. R. CARVACROL PROMOTES NEUROPROTECTION IN THE MOUSE HEMIPARKINSONIAN MODEL. Neuroscience, v. 356, p. 176-181, JUL 25 2017. Web of Science Citations: 10.
SIGNOR, CRISTIANE; GIRARDI, BRUNA AMANDA; WENDEL, ARITHANE LORENA; SANTANA FRUHAUF, PAMELLA KARINA; PILLAT, MICHELI M.; ULRICH, HENNING; MELLO, CARLOS F.; RUBIN, MARIBEL A. Spermidine improves the persistence of reconsolidated fear memory and neural differentiation in vitro: Involvement. NEUROBIOLOGY OF LEARNING AND MEMORY, v. 140, p. 82-91, APR 2017. Web of Science Citations: 3.
FERRAZOLI, ENEAS G.; DE SOUZA, HELLIO D. N.; NASCIMENTO, ISIS C.; OLIVEIRA-GIACOMELLI, AGATHA; SCHWINDT, TELMA T.; BRITTO, LUIZ R.; ULRICHT, HENNING. Brilliant Blue G, But Not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease. CELL TRANSPLANTATION, v. 26, n. 4, SI, p. 669-677, 2017. Web of Science Citations: 5.
PILLAT, MICHELI M.; LAMEU, CLAUDIANA; TRUJILLO, CLEBER A.; GLASER, TALITA; CAPPELLARI, ANGELICA R.; NEGRAES, PRISCILLA D.; BATTASTINI, ANA M. O.; SCHWINDT, TELMA T.; MUOTRI, ALYSSON R.; ULRICH, HENNING. Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation. Journal of Cell Science, v. 129, n. 18, p. 3437-3448, SEP 15 2016. Web of Science Citations: 4.
OLIVEIRA, AGATHA; ILLES, PETER; ULRICH, HENNING. Purinergic receptors in embryonic and adult neurogenesis. Neuropharmacology, v. 104, n. SI, p. 272-281, MAY 2016. Web of Science Citations: 20.
PILLAT, MICHELI M.; OLIVEIRA, MONA N.; MOTALN, HELENA; BREZNIK, BARBARA; GLASER, TALITA; LAH, TAMARA T.; ULRICH, HENNING. Glioblastoma-Mesenchymal Stem Cell Communication Modulates Expression Patterns of Kinin Receptors: Possible Involvement of Bradykinin in Information Flow. Cytometry Part A, v. 89A, n. 4, p. 365-375, APR 2016. Web of Science Citations: 7.
SCHNEIDER, GABRIELA; GLASER, TALITA; LAMEU, CLAUDIANA; ABDELBASET-ISMAIL, AHMED; SELLERS, ZACHARIAH PAYNE; MONIUSZKO, MARCIN; ULRICH, HENNING; RATAJCZAK, MARIUSZ Z. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Molecular Cancer, v. 14, NOV 24 2015. Web of Science Citations: 15.
NASCIMENTO, ISIS C.; GLASER, TALITA; NERY, ARTHUR A.; PILLAT, MICHELI M.; PESQUERO, JOAO B.; ULRICH, HENNING. Kinin-B1 and B2 receptor activity in proliferation and neural phenotype determination of mouse embryonic stem cells. Cytometry Part A, v. 87A, n. 11, p. 989-1000, NOV 2015. Web of Science Citations: 6.
CAPPELLARI, ANGELICA R.; PILLAT, MICHELI M.; SOUZA, HELLIO D. N.; DIETRICH, FABRICIA; OLIVEIRA, FRANCINE H.; FIGUEIRO, FABRICIO; ABUJAMRA, ANA L.; ROESLER, RAFAEL; LECKA, JOANNA; SEVIGNY, JEAN; BATTASTINI, ANA MARIA O.; ULRICH, HENNING. Ecto-5 `-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model. PLoS One, v. 10, n. 10 OCT 22 2015. Web of Science Citations: 8.
GLASER, TALITA; BUENO, VANIA B.; CORNEJO, DANIEL R.; PETRI, DENISE F. S.; ULRICH, HENNING. Neuronal adhesion, proliferation and differentiation of embryonic stem cells on hybrid scaffolds made of xanthan and magnetite nanoparticles. Biomedical Materials, v. 10, n. 4 AUG 2015. Web of Science Citations: 10.
MENCIN, NINA; SMUC, TINA; VRANICAR, MARKO; MAVRI, JAN; HREN, MATJAZ; GALESA, KATJA; KRKOC, PETER; ULRICH, HENNING; SOLAR, BORUT. Optimization of SELEX: Comparison of different methods for monitoring the progress of in vitro selection of aptamers. Journal of Pharmaceutical and Biomedical Analysis, v. 91, p. 151-159, MAR 25 2014. Web of Science Citations: 20.
NERY, ARTHUR A.; MAGDESIAN, MARGARET H.; TRUJILLO, CLEBER A.; SATHLER, LUCIANA B.; JULIANO, MARIA A.; JULIANO, LUIZ; ULRICH, HENNING; FERREIRA, SERGIO T. Rescue of Amyloid-Beta-Induced Inhibition of Nicotinic Acetylcholine Receptors by a Peptide Homologous to the Nicotine Binding Domain of the Alpha 7 Subtype. PLoS One, v. 8, n. 7 JUL 22 2013. Web of Science Citations: 7.
SMUC, TINA; AHN, IL-YOUNG; ULRICH, HENNING. Nucleic acid aptamers as high affinity ligands in biotechnology and biosensorics. Journal of Pharmaceutical and Biomedical Analysis, v. 81-82, p. 210-217, JUL-AUG 2013. Web of Science Citations: 50.
GLASER, TALITA; RESENDE, RODRIGO R.; ULRICH, HENNING. Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation. CELL COMMUNICATION AND SIGNALING, v. 11, FEB 17 2013. Web of Science Citations: 29.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180071661 - Universidade de São Paulo (USP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - April 2018, 09