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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Insights from Systems Biology in Physiological Studies: Learning from Context

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Imenez Silva, Pedro Henrique [1, 2] ; Melo, Diogo [3] ; Ribeiro de Mendonca, Pedro Omori [4, 5]
Total Authors: 3
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, Sao Paulo - Brazil
[2] Univ Zurich, Inst Physiol, Winterthurerstr 190, CH-8057 Zurich - Switzerland
[3] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, Sao Paulo - Brazil
[4] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Anat, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Review article
Source: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 42, n. 3, p. 939-951, 2017.
Web of Science Citations: 1

Systems biology presents an integrated view of biological systems, focusing on the relations between elements, whether functional or evolutionary, and providing a rich framework for the comprehension of life. At the same time, many low-throughput experimental studies are performed without influence from this integrated view, whilst high-throughput experiments use low-throughput results in their validation and interpretation. We propose an inversion in this logic, and ask which benefits could be obtained from a holistic view coming from high-throughput studies. and systems biology in particular. in interpreting and designing low-throughput experiments. By exploring some key examples from the renal and adrenal physiology, we try to show that network and modularity theory, along with observed patterns of association between elements in a biological system, can have profound effects on our ability to draw meaningful conclusions from experiments. (C) 2017 The Author(s) Published by S. Karger AG, Basel (AU)

FAPESP's process: 12/23535-4 - The role of POMC-derived peptides in differentiation and function of adrenal cortex
Grantee:Pedro Omori Ribeiro de Mendonça
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/26262-4 - Direct estimates of evolutionary parameters via quantitative trait loci analysis
Grantee:Diogo Amaral Reboucas Melo
Support type: Scholarships in Brazil - Doctorate